2024
ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritisMcBride DA, Wang JS, Johnson WT, Bottini N, Shah NJ. ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis. Biomater Sci. 2024 Feb 13. doi: 10.1039/d3bm01674a. Epub ahead of print. PMID: 38349277.
Ultrasound attenuation of cortical bone correlates with biomechanical, microstructural, and compositional propertiesJerban S, Barrere V, Namiranian B, Wu Y, Alenezi S, Dorthe E, Dlima D, Shah SB, Chung CB, Du J, Andre MP, Chang EY. Ultrasound attenuation of cortical bone correlates with biomechanical, microstructural, and compositional properties. Eur Radiol Exp. 2024 Feb 6;8(1):21. doi: 10.1186/s41747-023-00418-w. PMID: 38316687; PMCID: PMC10844174.
Biodegradable scaffolds for enhancing vaccine deliveryKerr MD, Johnson WT, McBride DA, Chumber AK, Shah NJ. Biodegradable scaffolds for enhancing vaccine delivery. Bioeng Transl Med. 2023 Aug 21;8(6):e10591. doi: 10.1002/btm2.10591. PMID: 38023723; PMCID: PMC10658593.
Immunomodulatory Nanoparticles for Modulating Arthritis FlaresJohnson WT, McBride D, Kerr M, Nguyen A, Zoccheddu M, Bollmann M, Wei X, Jones RM, Wang W, Svensson MND, Bottini N, Shah NJ. Immunomodulatory Nanoparticles for Modulating Arthritis Flares. ACS Nano. 2024 Jan 23;18(3):1892-1906. doi: 10.1021/acsnano.3c05298. Epub 2023 Nov 28. PMID: 38016062..
2023
Correlations between elastic modulus and ultrashort echo time (UTE) adiabatic T1ρ relaxation time (UTE-Adiab-T1ρ) in Achilles tendons and enthesesJerban S, Afsahi AM, Ma Y, Moazamian D, Statum S, Lombardi AF, Kakos L, Dorthe E, Dlima D, Du J, Chung CB, Chang EY. Correlations between elastic modulus and ultrashort echo time (UTE) adiabatic T1ρ relaxation time (UTE-Adiab-T1ρ) in Achilles tendons and entheses. J Biomech. 2023 Oct 4;160:111825. doi: 10.1016/j.jbiomech.2023.111825. Epub ahead of print. PMID: 37856976.
Deep-Learning-Aided Evaluation of Spondylolysis Imaged with Ultrashort Echo Time Magnetic Resonance ImagingAchar S, Hwang D, Finkenstaedt T, Malis V, Bae WC. Deep-Learning-Aided Evaluation of Spondylolysis Imaged with Ultrashort Echo Time Magnetic Resonance Imaging. Sensors (Basel). 2023 Sep 21;23(18):8001. doi: 10.3390/s23188001. PMID: 37766055; PMCID: PMC10538057.
Whole knee joint mapping using a phase modulated UTE adiabatic T1ρ (PM-UTE-AdiabT1ρ ) sequence Ma Y, Carl M, Tang Q, Moazamian D, Athertya JS, Jang H, Bukata SV, Chung CB, Chang EY, Du J. Whole knee joint mapping using a phase modulated UTE adiabatic T1ρ (PM-UTE-AdiabT1ρ ) sequence. Magn Reson Med. 2024 Mar;91(3):896-910. doi: 10.1002/mrm.29871. Epub 2023 Sep 27. PMID: 37755319; PMCID: PMC10843531.
Achilles tendon and enthesis assessment using ultrashort echo time magnetic resonance imaging (UTE-MRI) T1 and magnetization transfer (MT) modeling in psoriatic arthritisMoazamian D, Athertya JS, Dwek S, Lombardi AF, Mohammadi HS, Sedaghat S, Jang H, Ma Y, Chung CB, Du J, Jerban S, Chang EY. Achilles tendon and enthesis assessment using ultrashort echo time magnetic resonance imaging (UTE-MRI) T1 and magnetization transfer (MT) modeling in psoriatic arthritis. NMR Biomed. 2024 Jan;37(1):e5040. doi: 10.1002/nbm.5040. Epub 2023 Sep 23. PMID: 37740595; PMCID: PMC10754405.
T1rho MR properties of human patellar cartilage: correlation with indentation stiffness and biochemical contentsBae WC, Statum S, Masuda K, Chung CB. T1rho MR properties of human patellar cartilage: correlation with indentation stiffness and biochemical contents. Skeletal Radiol. 2024 Apr;53(4):649-656. doi: 10.1007/s00256-023-04458-6. Epub 2023 Sep 23. PMID: 37740079.
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblastsSendo S, Kiosses WB, Yang S, Wu DJ, Lee DWK, Liu L, Aschner Y, Vela AJ, Downey GP, Santelli E, Bottini N. Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts. Sci Signal. 2023 Jul 4;16(792):eabn8668. doi: 10.1126/scisignal.abn8668. Epub 2023 Jul 4. PMID: 37402225; PMCID: PMC10544828.
3D T1rho sequences with FASE, UTE, and MAPSS acquisitions for knee evaluationBae WC, Malis V, Kassai Y, Miyazaki M. 3D T1rho sequences with FASE, UTE, and MAPSS acquisitions for knee evaluation. Jpn J Radiol. 2023 Nov;41(11):1308-1315. doi: 10.1007/s11604-023-01453-8. Epub 2023 May 29. PMID: 37247122.
Ultrashort time-to-echo MR morphology of cartilaginous endplate correlates with disc degeneration in the lumbar spineFinkenstaedt T, Siriwananrangsun P, Masuda K, Bydder GM, Chen KC, Bae WC. Ultrashort time-to-echo MR morphology of cartilaginous endplate correlates with disc degeneration in the lumbar spine. Eur Spine J. 2023 Jul;32(7):2358-2367. doi: 10.1007/s00586-023-07739-9. Epub 2023 May 17. PMID: 37195362.
Correction of B0 and linear eddy currents: Impact on morphological and quantitative ultrashort echo time double echo steady state (UTE-DESS) imagingJang H, Athertya JS, Jerban S, Ma Y, Lombardi AF, Chung CB, Chang EY, Du J. Correction of B0 and linear eddy currents: Impact on morphological and quantitative ultrashort echo time double echo steady state (UTE-DESS) imaging. NMR Biomed. 2023 Mar 25:e4939. doi: 10.1002/nbm.4939. Epub ahead of print. PMID: 36965076; PMCID: PMC10518369.
Robust Assessment of Macromolecular Fraction (MMF) in Muscle with Differing Fat Fraction Using Ultrashort Echo Time (UTE) Magnetization Transfer Modeling with Measured T1Jerban S, Ma Y, Tang Q, Fu E, Szeverenyi N, Jang H, Chung CB, Du J, Chang EY. Robust Assessment of Macromolecular Fraction (MMF) in Muscle with Differing Fat Fraction Using Ultrashort Echo Time (UTE) Magnetization Transfer Modeling with Measured T1. Diagnostics (Basel). 2023 Feb 24;13(5):876. doi: 10.3390/diagnostics13050876. PMID: 36900019; PMCID: PMC10001337.
Immune-responsive biodegradable scaffolds for enhancing neutrophil regenerationKerr MD, McBride DA, Johnson WT, Chumber AK, Najibi AJ, Seo BR, Stafford AG, Scadden DT, Mooney DJ, Shah NJ. Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration. Bioeng Transl Med. 2022 Apr 19;8(1):e10309. doi: 10.1002/btm2.10309. PMID: 36684088; PMCID: PMC9842036.
Jerban S, Ma Y, Alenezi S, Moazamian D, Athertya J, Jang H, Dorthe E, Dlima D, Woods G, Chung CB, Chang EY, Du J. Ultrashort Echo Time (UTE) MRI porosity index (PI) and suppression ratio (SR) correlate with the cortical bone microstructural and mechanical properties: Ex vivo study. Bone. 2023 Apr;169:116676. doi: 10.1016/j.bone.2023.116676. Epub 2023 Jan 16. PMID: 36657630.
Cheng KY, Moazamian D, Ma Y, Jang H, Jerban S, Du J, Chung CB. Clinical application of ultrashort echo time (UTE) and zero echo time (ZTE) magnetic resonance (MR) imaging in the evaluation of osteoarthritis. Skeletal Radiol. 2023 Jan 6. doi: 10.1007/s00256-022-04269-1. Epub ahead of print. PMID: 36607355.
Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitroMcBride DA, Dorn NC, Yao M, Johnson WT, Wang W, Bottini N, Shah NJ. Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro. Drug Deliv Transl Res. 2023 Jul;13(7):1912-1924. doi: 10.1007/s13346-022-01284-6. Epub 2022 Dec 24. PMID: 36566262; PMCID: PMC10695156.
Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applicationsMa Y, Jang H, Jerban S, Chang EY, Chung CB, Bydder GM, Du J. Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications. Appl Phys Rev. 2022 Dec;9(4):041303. doi: 10.1063/5.0086459. PMID: 36467869; PMCID: PMC9677812.
Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor functionAinsworth RI, Hammaker D, Nygaard G, Ansalone C, Machado C, Zhang K, Zheng L, Carrillo L, Wildberg A, Kuhs A, Svensson MND, Boyle DL, Firestein GS, Wang W. Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function. Nat Commun. 2022 Oct 20;13(1):6221. doi: 10.1038/s41467-022-33785-w. PMID: 36266270; PMCID: PMC9584907.
Ultrashort echo time magnetic resonance imaging of the osteochondral junctionLombardi AF, Guma M, Chung CB, Chang EY, Du J, Ma YJ. Ultrashort echo time magnetic resonance imaging of the osteochondral junction. NMR Biomed. 2023 Feb;36(2):e4843. doi: 10.1002/nbm.4843. Epub 2022 Nov 20. PMID: 36264245; PMCID: PMC9845195.
Synthetic CT in Musculoskeletal Disorders: A Systematic ReviewLombardi AF, Ma YJ, Jang H, Jerban S, Du J, Chang EY, Chung CB. Synthetic CT in Musculoskeletal Disorders: A Systematic Review. Invest Radiol. 2023 Jan 1;58(1):43-59. doi: 10.1097/RLI.0000000000000916. Epub 2022 Aug 29. PMID: 36070535; PMCID: PMC9742139.
2022
Boyle DL, Prideaux EB, Hillman J, Wang W, Firestein GS. Improving Transcriptome Fidelity Following Synovial Tissue Disaggregation. ront Med (Lausanne). 2022 Aug 10;9:919748. doi: 10.3389/fmed.2022.919748. PMID: 36035425; PMCID: PMC9400013.
Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 Aug 9;55(8):1370-1385.e8. doi: 10.1016/j.immuni.2022.06.007. Epub 2022 Jul 13. PMID: 35835107; PMCID: PMC9378606.
Supported by the MARC through the
Pilot Project Grant program. Hsieh LE, Song J, Tremoulet AH, Burns JC, Franco A. Intravenous immunoglobulin induces IgG internalization by tolerogenic myeloid dendritic cells that secrete IL-10 and expand Fc-specific regulatory T cells. Clin Exp Immunol. 2022 Jun 23;208(3):361-371. doi: 10.1093/cei/uxac046. PMID: 35536993; PMCID: PMC9226148.
Supported by the MARC through the
Pilot Project Grant program.
Hurysz B, Bottini N. Emerging proteoglycans and proteoglycan-targeted therapies in rheumatoid arthritis. Am J Physiol Cell Physiol. 2022 Jun 1;322(6):C1061-C1067. doi: 10.1152/ajpcell.00086.2022. Epub 2022 Apr 27. PMID: 35476502; PMCID: PMC9169851.
Miyazaki M, Yamamoto A, Malis V, Statum S, Chung CB, Sozanski J, Bae WC. Time-Resolved Noncontrast Magnetic Resonance Perfusion Imaging of Paraspinal Muscles. J Magn Reson Imaging. 2022 Feb 22. doi: 10.1002/jmri.28123. Epub ahead of print. PMID: 35191562.
Synovial inflammation in osteoarthritis progression
Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022 May;18(5):258-275. doi: 10.1038/s41584-022-00749-9. Epub 2022 Feb 14. PMID: 35165404; PMCID: PMC9050956.
Supported by the MARC through the
Pilot Project Grant program.
Torres A, Pedersen B, Cobo I, Ai R, Coras R, Murillo-Saich J, Nygaard G, Sanchez-Lopez E, Murphy A, Wang W, Firestein GS, Guma M. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2022 Jul;74(7):1159-1171. doi: 10.1002/art.42077. Epub 2022 Jun 2. PMID: 35128827; PMCID: PMC9246826.
Hsieh LE, Grifoni A, Sidney J, Shimizu C, Shike H, Ramchandar N, Moreno E, Tremoulet AH, Burns JC, Franco A. Characterization of SARS-CoV-2 and common cold coronavirus-specific T-cell responses in MIS-C and Kawasaki disease children. Eur J Immunol. 2022 Jan;52(1):123-137. doi: 10.1002/eji.202149556. Epub 2021 Oct 27. PMID: 34599760; PMCID: PMC8646471.
Supported by the MARC through the
Pilot Project Grant program.
2021
Jang H, Ma Y, Carl M, Lombardi AF, Chang EY, Du J. Feasibility of an Inversion Recovery-Prepared Fat-Saturated Zero Echo Time Sequence for High Contrast Imaging of the Osteochondral Junction. Front Endocrinol (Lausanne). 2021 Dec 24;12:777080. doi: 10.3389/fendo.2021.777080. PMID: 35002964; PMCID: PMC8739813.
Hsieh LE, Grifoni A, Dave H, Wang J, Johnson D, Zellner J, Sidney J, Chambers C, Franco A. SARS-CoV-2-specific T cell responses and immune regulation in infected pregnant women. J Reprod Immunol. 2022 Feb;149:103464. doi: 10.1016/j.jri.2021.103464. Epub 2021 Dec 11. PMID: 34953325; PMCID: PMC8665650.
Supported by the MARC through the
Pilot Project Grant program.
©
ImmunoHorizons Figueroa MG, Parker LM, Krol K, Zhao M. Distal
LckPromoter-Driven Cre Shows Cell Type-Specific Function in Innate-like T Cells. Immunohorizons. 2021 Sep 28;5(9):772-781. doi: 10.4049/immunohorizons.2100079. PMID: 34583938.
Supported by the MARC through the
Pilot Project Grant program. Kim S, Jang H, Hong S, Hong YS, Bae WC, Kim S, Hwang D. Fat-saturated image generation from multi-contrast MRIs using generative adversarial networks with Bloch equation-based autoencoder regularization. Med Image Anal. 2021 Oct;73:102198. doi: 10.1016/j.media.2021.102198. Epub 2021 Jul 30. PMID: 34403931.
Zhao M, Quintana A, Zhang C, Andreyev AY, Kiosses W, Kuwana T, Murphy A, Hogan PG, Kronenberg M. Calcium signals regulate the functional differentiation of thymic iNKT cells. EMBO J. 2021 Aug 16;40(16):e107901. doi: 10.15252/embj.2021107901. Epub 2021 Jun 25. PMID: 34169542; PMCID: PMC8365263. Reproduced with permission from EMBO.
Supported by the MARC through the
Pilot Project Grant program.
Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 Jul 13;54(7):1463-1477.e11. doi: 10.1016/j.immuni.2021.05.004. Epub 2021 Jun 10. PMID: 34115964; PMCID: PMC8189765.
Supported by the MARC through the
Pilot Project Grant program.
Bae WC. Editorial for "In Vivo Assessment of Age- and Loading Configuration-Related Changes in Multiscale Mechanical Behavior of the Human Proximal Femur Using MRI-Based Finite Element Analysis". J Magn Reson Imaging. 2021 Mar;53(3):913-914. doi: 10.1002/jmri.27427. Epub 2020 Nov 6. PMID: 33155743.
McBride DA, Kerr MD, Dorn NC, Ogbonna DA, Santos EC, Shah NJ. Triggers, Timescales, and Treatments for Cytokine-Mediated Tissue Damage. Euro Med J Innov. 2021 Feb;5(1):52-62. doi: 10.33590/emjinnov/20-00203. Epub 2020 Dec 9. PMID: 34013158; PMCID: PMC8130813.
Supported by the MARC through the
Pilot Project Grant program.
Quantitative magnetic resonance imaging of meniscal pathology ex vivo
Bae WC, Tadros AS, Finkenstaedt T, Du J, Statum S, Chung CB. Quantitative magnetic resonance imaging of meniscal pathology ex vivo. Skeletal Radiol. 2021 Dec;50(12):2405-2414. doi: 10.1007/s00256-021-03808-6. Epub 2021 May 13. PMID: 33983499; PMCID: PMC8536602.
2020
Hsieh WC, Svensson MN, Zoccheddu M, Tremblay ML, Sakaguchi S, Stanford SM, Bottini N. PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. JCI Insight. 2020 Oct 15;5(20):141868. doi: 10.1172/jci.insight.141868. PMID: 33055428.
Daisuke Fukui, Koichi Masuda, Michael Zimber, Stephanie Y. Adachi, Natsuko Arimoto, Jeong Ho Kim, … Gail K. Naughton*. A Novel Bioengineered Material to Reverse Intervertebral Disc Degeneration. Journal of Medicine and Surgical Sciences, 2020 May, 2(1), 1–10. http://doi.org/10.5281/zenodo.3777266.
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020 Jun 26;6(26):eaba4353. doi: 10.1126/sciadv.aba4353. PMID: 32637608; PMCID: PMC7319753.
Highlighted in Natural Reviews Rheumatology:
Therapies targeting FLS and TNF can have synergistic effects (November 2020)
Ariyachaipanich A, Kaya E, Statum S, Biswas R, Tran B, Bae WC, Chung CB. MR imaging pattern of tibial subchondral bone structure: considerations of meniscal coverage and integrity. Skeletal Radiol. 2020 Dec;49(12):2019-2027. doi: 10.1007/s00256-020-03517-6. Epub 2020 Jun 26. PMID: 32591855; PMCID: PMC7658005.
McBride DA, Kerr MD, Wai SL, Yee YY, Ogbonna DA, Shah NJ. Characterization of
regulatory T cell expansion for manufacturing cellular immunotherapies. Biomaterials
science. 2020 May 22. PubMed PMID: 32441280; DOI: 10.1039/d0bm00622j.
Supported by the MARC through the
Pilot Project Grant program.
Alique M, Sánchez-López E, Bodega G, Giannarelli C, Carracedo J, Ramírez R. Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging. Cells. 2020 Jan 13;9(1):195. doi: 10.3390/cells9010195. PMID: 31941032; PMCID: PMC7016968.
Supported by the MARC through the
Pilot Project Grant program.
Wang Z, Zhao Y, Phipps-Green A, Liu-Bryan R, Ceponis A, Boyle DL, Wang J, Merriman TR, Wang W, Terkeltaub R. Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout. Arthritis Rheumatol. 2020 May;72(5):802-814. doi: 10.1002/art.41173. Epub 2020 Mar 23. PMID: 31738005; PMCID: PMC7323903.
Supported by the MARC through the
Pilot Project Grant program.
2019
McBride DA, Kerr MD, Wai SL, Shah NJ. Applications of molecular engineering in T-cell-based immunotherapies. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Sep;11(5):e1557. doi: 10.1002/wnan.1557. Epub 2019 Apr 10. PMID: 30972976; PMCID: PMC7869905.
Finkenstaedt T, Biswas R, Abeydeera NA, Siriwanarangsun P, Healey R, Statum S, Bae WC, Chung CB. Ultrashort Time to Echo Magnetic Resonance Evaluation of Calcium Pyrophosphate Crystal Deposition in Human Menisci. Invest Radiol. 2019 Jun;54(6):349-355. doi: 10.1097/RLI.0000000000000547. PMID: 30688685; PMCID: PMC6499636.