Selected Publications

Elenara da Fonseca Andrade Procianoy; · Fernando Antônio de Abreu e Silva; ·Paulo José Cauduro Maróstica; Paul M. Quinton. "Chloride Conductance, Nasal Potential Difference and Cystic Fibrosis Pathophysiology." Lung 198(1):151-156, 2020.
Carla Cristina Souza Gomez1 · Paloma Lopes Francisco Parazzi1 · Karl Jan Clinckspoor2 ·Renan Marrichi Mauch1 · Francisco Benedito Teixeira Pessine2 · Carlos Emilio Levy3 · Andressa Oliveira Peixoto1 ·Maria Ângela Gonçalves Oliveira Ribeiro1 · Antônio Fernando Ribeiro1 · Douglas Conrad4 · Paul Marquis Quinton5 ,·Fernando Augusto Lima Marson1,· José Dirceu Ribeiro1. "Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis", Clin Drug Investig. 40(2):105-117, 2020
Shamsuddin, A. K. M. and P. M. Quinton. Concurrent Absorption and Secretion of Airway Surface Liquids and Bicarbonate Secretion in Human Bronchioles." American Journal of Physiology. Lung cellular and molecular physiology, 316(5):L953- L960, 2019
Dobay, O., Laub, K., Stercz, B., Keri, A., Balazs, B., Tothpal, A., Kardos, S., Jaikumpun, P., Ruksakiet, K., Quinton, P. M., Zsembery, A. Bicarbonate Inhibits Bacterial Growth and Biofilm Formation of Prevalent Cystic Fibrosis Pathogens. Front Microbiol 9: 2245, 2018.
Quinton, P. M.. 'Both Ways at Once: Keeping Small Airways Clean', Physiology (Bethesda), 32: 380-90. 2017
Salinas D B, Kang L, Azen C, and Quinton P. Low Beta-Adrenergic Sweat Responses in Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator-Related Metabolic Syndrome Children, Ped Allergy Immunol Pulmon, 30:2-6, 2017.
Flores-Delgado, G., C. Lytle, P.M. Quinton. Site of Fluid Secretion in Small Airways. Am J Respir Cell Mol Biol.. Mar 12, 2016.
Ferkol, T., and P. Quinton. 2015. Precision Medicine: At What Price? Am J Respir Crit Care Med 192:658-659.
Orenstein, D.M., B.P. O'Sullivan, and P.M. Quinton. 2015. Cystic Fibrosis: Breakthrough Drugs at Break-the-Bank Prices. Glob Adv Health Med 4:8-57.
Shamsuddin, A.K., and P.M. Quinton. Native small airways secrete bicarbonate. Am J Respir Cell Mol Biol 50:796-804, 2014.
Shepherd, S.L., E.J. Goodrich, J. Desch, and P.M. Quinton. Rebuttal from Mr Shepherd et al. Chest 145:684-685, 2014.
Shepherd, S.L., E.J. Goodrich, J. Desch, and P.M. Quinton. Counterpoint: does the risk of cross infection warrant exclusion of adults with cystic fibrosis from cystic fibrosis foundation events? No. Chest 145:680-683, 2014.
Quinton, P. The Time is Now: The Critical Need for Increased Research Funding, CFRI News, Spring 2014
Quinton, P.M., G., D. Worlitzsch. Obituary Gerd Döring. The International Journal of Biochemistry & Cell Biology, 52:5-6, 2014
Quinton, P. M. 2014. 'A synopsis of methods of sweat tests in pathology', Clin Biochem, 47: 757-8.
Yang, N., M.A. Garcia, and P.M. Quinton. Normal mucus formation requires cAMP-dependent HCO3- secretion and Ca2+-mediated mucin exocytosis. J Physiol 591:4581-4593, 2013.
Cooper, JL, P Quinton, and Ballard. Mucociliary Transport in Porcine Trachea: Differential Effects of Inhibiting Chloride and Bicarbonate Secretion. Am J Physiol Lung Cell Mol Physiol 304:L184-190, 2013.
Quinton, P. ¿Que es la investigacion? ECOS de FIPAN, April 2013
Quinton, P., L. Molyneux, W. Ip, A. Dupuis, J. Avolio, E. Tullis, D. Conrad, A.K. Shamsuddin, P. Durie, and T. Gonska. Beta-adrenergic sweat secretion as a diagnostic test for cystic fibrosis. Am J Respir Crit Care Med 186:732-739, 2012.
Shamsuddin, A.K., and P.M. Quinton. Surface fluid absorption and secretion in small airways. J Physiol 590:3561-3574, 2012.
Quinton, P. A New View: Cystic Fibrosis, Mucus, and Baking Soda. CFRI News, Fall 2011
Chen EY, Yang N, Quinton PM, and Chin WC. A New Role for Bicarbonate in Mucus Formation. Am J Physiol Lung Cell Mol Physiol 299:L542-549, 2010.
RW Muchekehu and PM Quinton. Mucus release in the female reproductive tract is critically dependent on bicarbonate. J Physiol 588: 2329-2342, 2010.
Gonska T, Ip W, Turner D, WonSun Han, Rose J, Durie P, Quinton P. Sweat gland bioelectrics differ in cystic fibrosis: a new concept for potential diagnosis and assessment of CFTR function in cystic fibrosis. Thorax. Nov;64(11):932-8, 2009.
Garcia MA, Yang N, and Quinton PM. Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion. J Clin Invest 119: 2613-2622, 2009.
Reddy, MM and Quinton, PM. PKA Mediates Constitutive Activation of CFTR in Human Sweat Duct. J. Membrane Biol. 2009 Oct;231(2-3):65-78
Reddy MM, Wang XF, Quinton PM. Effect of Cytosolic pH on Epithelial Na(+) Channel in Normal and Cystic Fibrosis Sweat Ducts. J Membr Biol 225: 1-11, 2008.
Shamsuddin AK, Reddy MM, Quinton PM. Iontophoretic {beta}-adrenergic Stimulation of Human Sweat Glands: Possible Assay for CFTR Activity In Vivo. Exp Physiol. 2008 Apr 25.
Quinton PM. Cystic Fibrosis: Impaired HCO3- Secretion and Mucoviscidosis. Lancet. In Press.
Quinton PM. Too much salt, too little soda: cystic fibrosis. Sheng Li XueBao. 2007 Aug 25;59(4):397-415.
Quinton PM. Cystic fibrosis: lessons from the sweat gland. Physiology (Bethesda). 2007 Jun;22(3):212-25
Wang X, Lytle C, Quinton PM. Predominant constitutive CFTR conductance in small airways. Respir Res. 2005 Jan 17;6(1):7-19.
Reddy MM, Wang XF, Gottschalk M, Jones K, Quinton PM. Normal CFTR Activity and Reversed Skin Potentials in Pseudohypoaldosteronism. J Membr Biol. 2005 Feb;203(3):151-9.
Reddy MM, Quinton PM. Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells. Nature. 2003 12 June 2003;423:756 - 60.
Quinton PM. The neglected ion: HCO3. Nature medicine. 2001 Mar;7(3):292-3.
Reddy MM, Light MJ, Quinton PM. Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function. Nature. 1999 Nov 18;402(6759):301-4.
Quinton PM. Physiological basis of cystic fibrosis: a historical perspective. Physiol Rev. 1999 Jan;79(1):S3-S22.
Quinton PM. Human genetics. What is good about cystic fibrosis? Curr Biol. 1994 Aug 1;4(8):742-3.
Joris L, Dab I, Quinton PM. Elemental composition of human airway surface fluid in healthy and diseased airways. Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1633-7.
Quinton PM, Reddy MM. Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding. Nature. 1992 Nov 5;360(6399):79-81.
Quinton PM. Cystic fibrosis. Righting the wrong protein. Nature. 1990 Sep 20;347(6290):226.
Reddy MM, Quinton PM. Localization of Cl- conductance in normal and Cl- impermeability in cystic fibrosis sweat duct epithelium. Am J Physiol. 1989 Oct;257(4 Pt 1):C727-35.
Riordan J, Burns J, Tsui LC, Reddy MM, Quinton P, Buchwald M. Utilization of cultured epithelial cells from the sweat gland in studies of the CF defect. ProgClinBiol Res. 1987;254:59-71.
Joris L, Quinton PM. Concentration of elements in airway surface fluid. Medical Science Research. 1987;15:855-6.
Quinton PM, Bijman J. Higher bioelectric potentials due to decreased chloride absorption in the sweat glands of patients with cystic fibrosis. N Engl J Med. 1983 May 19;308(20):1185-9.
Quinton PM. Chloride impermeability in cystic fibrosis. Nature. 1983 Feb 3;301(5899):421-2.
Quinton PM. Composition and control of secretions from tracheal bronchial submucosal glands. Nature. 1979 Jun 7;279(5713):551-2.
Quinton PM. Techniques for microdrop analysis of fluids (sweat, saliva, urine) with an energy-dispersive X-ray spectrometer on a scanning electron microscope. Am J Physiol. 1978 Mar;234(3):F255-9.
Prompt CA, Quinton PM. Functions of calcium in sweat secretion. Nature. 1978 Mar 9;272(5649):171-2.
Quinton PM, Tormey JM. Localization of Na/K-ATPase sites in the secretory and reabsorptive epithelia of perfused eccrine sweat glands: a question to the role of the enzyme in secretion. J Membr Biol. 1976 Nov 29;29(4):383-99.
Quinton PM, Philpott CW. A role for anionic sites in epithelial architecture. Effects of cationic polymers on cell membrane structure. J Cell Biol. 1973 Mar;56(3):787-96.