Tsai CM, Caldera JR, Hajam IA, Chiang AWT, Tsai CH, Li H, Díez ML, Gonzalez C, Trieu D, Martins GA, Underhill DM, Arditi M, Lewis NE, Liu GY. Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine. Cell Host Microbe. 2022 08 10; 30(8):1163-1172
The publication above was featured in "A Staph Vaccine Trial Failure Shows Challenges of Stopping Common Bugs."
Kolar SL, Tsai CM, Torres J, Fan
X, Li H, Liu GY. Propionibacterium acnes-induced immunopathology correlates
with health and disease association. JCI
Insight. 2019
Mar 07; 4(5). PMID: 30843879.
Das MM, Godoy M, Chen S, Moser
VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS.
Young bone marrow transplantation preserves learning and memory in old mice. Commun Biol. 2019;
2:73. PMID: 30820468.
Khan Z, Cao DY, Giani
JF, Bernstein EA, Veiras LC, Fuchs S, Wang Y, Peng Z, Kalkum
M, Liu GY, Bernstein KE. Overexpression of the C-domain of
angiotensin-converting enzyme reduces melanoma growth by stimulating M1
macrophage polarization. J Biol Chem. 2019
Jan 22. PMID: 30670595.
Mikheyeva
IV, Thomas JM, Kolar SL, Corvaglia AR, Ga?a N, Leo S, Francois P, Liu GY, Rawat M, Cheung AL. YpdA,
a putative bacillithiol
disulfide reductase, contributes to cellular redox homeostasis and virulence in
Staphylococcus aureus. Mol Microbiol.
2019 Jan 12. PMID: 30636083.
Thomsen IP, Liu GY. Targeting
fundamental pathways to disrupt Staphylococcus aureus survival: clinical
implications of recent discoveries. JCI
Insight.
2018 Mar 08; 3(5). PMID: 29515041.
Sanchez M, Kolar SL, Müller S,
Reyes CN, Wolf AJ, Ogawa C, Singhania R, De Carvalho DD, Arditi M, Underhill
DM, Martins GA*, Liu GY*. O-Acetylation of Peptidoglycan Limits Helper T Cell
Priming and Permits Staphylococcus aureus Reinfection. Cell Host Microbe.
2017 Oct 11; 22(4):543-551.e4. PMID: 28943328.
Khan Z, Shen XZ, Bernstein EA, Giani
JF, Eriguchi
M, Zhao TV, Gonzalez-Villalobos RA, Fuchs S, Liu GY, Bernstein KE.
Angiotensin-converting enzyme enhances the oxidative response and bactericidal
activity of neutrophils. Blood.
2017 07 20; 130(3):328-339. PMID: 28515091.
Tseng CW, Biancotti JC, Berg BL,
Gate D, Kolar SL, Muller S, Rodriguez MD, Rezai-Zadeh K, Fan X, Beenhouwer DO,
Town T, Liu GY. Increased susceptibility of humanized NSG mice to
Panton-Valentine leukocidin and Staphylococcus aureus skin infection. PLOS Pathog.
2015;11(11):e1005292.
Sabrina Müller, Wolf AJ, Iliev
ID, Berg BL, Underhill DM*, Liu GY*. Poorly cross-linked peptidoglycan in
MRSA due to mecA induction activates the inflammasome and exacerbates
immunopathology. Cell Host Microbe.
2015;18(5):604-612.
Tseng CW, Liu GY. Expanding
roles of neutrophils in aging hosts. Curr Opin Immunol. 2014
Aug;29:43-48.
Kyme P, Thoennissen NH, Tseng CW,
Iwanski
GB, Shimada K, Krug UO, Lee K, Hardy WD, Gombart AF, Koeffler HP*, Liu
GY*. C/EBPε
mediates nicotinamide-enhanced clearance of Staphylococcus aureus in
mice. J Clin Invest.
2012;122(9):3316-3329.
Kolar SL, Liu GY. RAS and
ROS - A Story of Pseudomonas Survival. Cell
Host Microbe. 2017 May 10; 21(5):551-552. PMID:
28494232.
Wolf AJ, Liu GY, Underhill DM.
Inflammatory properties of antibiotic-treated bacteria. J Leukoc Biol.
2017 01; 101(1):127-134. PMID: 27576461.
Kolar S, Kyme P, Tseng CW,
Soliman A, Kaplan A, Liang J, Nizet V, Jiang D, Murali R, Arditi M, Underhill
DM, Liu GY. Group B Streptococcus evades host immunity by degrading
hyaluronan. Cell Host Microbe.
2015;18(6):694-704.
Park B, Liu GY. Targeting
the host-pathogen interface for treatment of Staphylococcus aureus
infection. Sem Immunopath. 2012;34(2):299-
Shimada T, Park B, Goodridge HS,
Wolf AJ, Becker CA, Reyes CN, Miao EA, Aderem
A, Götz F, Liu GY, Underhill DM. Staphylococcus aureus evades
lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome
activation and IL-1beta secretion. Cell
Host Microbe. 2010;7(1):38-49.
Tseng CW, Kyme P, Low J, Rocha
MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM,
Beenhouwer DO, Liu GY. Staphylococcus aureus Panton-Valentine leukocidin
contributes to inflammation and muscle tissue injury. PLOS ONE.
2009;4(7):e6837.
Liu GY, Nizet V. Color me bad:
microbial pigments as virulence factors. Trends
Microbiol. 2009;17(9):406-413.
Liu C-I*, Liu GY*, Song Y*,
Yin F, Hensler ME, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis
inhibitor blocks Staphylococcus aureus virulence. Science.
2008;319(5868):1391-1394.
Park B, Nizet V, Liu GY.
Role of Staphylococcus aureus catalase in niche competition against
Streptococcus pneumoniae. J Bacteriol.
2008;190(7):2275-2278.
Liu GY, Essex A, Buchanan JT,
Datta V, Fierer J, Nizet V. Staphylococcus aureus golden pigment impairs
neutrophil killing and promotes virulence through its antioxidant
activity. J Exp Med.
2005;202(2):209-215.
Liu GY, Doran K, Lawrence T,
Turkson N, Puliti
M, Tissi
L, Nizet V. Sword and shield: linked group B streptococcal
β-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte
defense. Proc Natl Acad Sci USA. 2004;101(40):14491-14496.
Doran K., Liu GY, Nizet V.
Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling
pathways in brain endothelium and contributes to development of
meningitis. J Clin Invest.
2003;112(5):736-744.
Liu, GY, Fairchild, PJ, Smith,
RM, Prowle,
JR, Koussis,
D, Wraith, DC. Low avidity recognition of self-antigen by T cells permits
escape from central tolerance. Immunity.
1995;3(4):407-415.