Pathology Research Lecture Series Archive

Click here to view the current Pathology Conference schedule.


Monday, September 13, 2021
Bing Ren, Ph.D.
UC San Diego Department of Cellular and Molecular Medicine
"Interpreting Disease Risk Variants by Single Cell Epigenomics"

Monday, September 20, 2021
Eunhee (Joanne) E. Yi, M.D.
Mayo Clinic
"Approaches to Diffuse Infiltrative Lung Diseases: Discussion of 3 Selected Cases"

Monday, September 27, 2021
Kun Zhang, Ph.D.
UC San Diego Department of Bioengineering
"How to Build a Comprehensive Cell Map for the Human Kidney"

Monday, October 4, 2021
Justin J. Taylor, Ph.D.
Fred Hutchinson Cancer Research Center
"Analysis and Engineering of Antigen-Specific B Cells"

Monday, October 11, 2021
Weizhou Zhang, Ph.D.
University of Florida Health Cancer Center
"Targeting Human Cancer Regulatory T Cells"

Monday, October 18, 2021
Walter L. Kemp, M.D., Ph.D.
University of North Dakota School of Medicine and Health Sciences
"Child Abuse or Not: Instructive Cases Combined with Some Research"

Monday, October 25, 2021
Henry D. Tazelaar, M.D.
Mayo Clinic
"Searching for Meaning in Granulomatous Lung Disease"

Monday, November 1, 2021
Fabian Rivera-Chávez, Ph.D.
UC San Diego Department of Pediatrics
"Modulation of Host-Microbe Metabolism by Cholera Toxin"

Monday, November 8, 2021
Richard R. Drake, Ph.D.
Medical University of South Carolina
"Linking Glycan and Extracellular Matrix Imaging Mass Spectrometry Approaches with Histopathology Correlates for Molecular Tumor Tissue Analysis"

Monday, November 15, 2021
Jing Yang, Ph.D.
UC San Diego Department of Pharmacology and Pediatrics
"Epithelial-Mesenchymal Plasticity in Tumor Metastasis"

Monday, November 29, 2021
Tristan Rutland
Western Sydney University
"Colorectal Carcinoma, East to Learn but Hard to Master?"

Monday, December 6, 2021
Jeffrey Spraggins, Ph.D.
Vanderbilt University
"Mutlimodal Imaging Mass Spectrometry: Connecting Omics and Imaging to Discover Molecular Drivers of Health and DIsease"

Monday, December 13, 2021
Jing Chen, Ph.D.
The University of Chicago
"Signaling Basis Underlying Cancer Metabolism"


Monday, September 14, 2020

Paul Mischel, M.D.
UC San Diego Department of Pathology
"Form Follows Function: The Role of Extrachromosomal DNA in Cancer"

Monday, September 21, 2020
Dannielle D. Engle, Ph.D.
The Salk Institute
"Aberrant Glycosylation Promotes Pancreatic Disease"

Monday, September 28, 2020
Dan S. Kaufman, M.D., Ph.D.
UC San Diego Department of Medicine
"Engineered Human Pluripotent Stem Cell-Derived Lymphocytes With Improved Anti-Tumor Activity"

Monday, October 5, 2020
Hannah Carter, Ph.D.
UC San Diego Department of Medicine
"Evolutionary Pressure Against the MHC Restricted Tumor Genome"

Monday, October 12, 2020
Viviana Gradinaru, Ph.D.
California Institute of Technology
"Engineered Gene Delivery Vectors and Microbial Opsins for High-Precision Minimally-Invasive Study and Repair of Diseased Nervous Systems Across Species"

Monday, October 19
Jack Bui, M.D., Ph.D.
UC San Diego Department of Pathology
"IL-17D, Exosomes, and IFNs in Cancer and Pathogen Immunity"

Monday, October 26, 2020
Aryeh Warmflash, Ph.D.
Rice University
"Studying Early Mammalian Development With Self-Organizing Embryonic Stem Cell Systems"

Monday, November 2, 2020
Alana L. Welm, Ph.D.
University of Utah School of Medicine
"Metastatic Breast Cancer: New Models and Treatment Strategies"

Monday, November 9, 2020
Robert Schooley, M.D.
UC San Diego Department of Medicine
"COVID-19: Progress Towards Controlling the Pandemic"

Monday, November 16, 2020
Stephen Schoenberger, Ph.D.
La Jolla Institute for Immunology
"Functional Identification and Therapeutic Targeting of Cancer"

Monday, November 30, 2020
Jean Zhao, Ph.D.
Harvard Medical School
"Integrating Immunotherapy and Targeted Therapy in Cancer Treatment: Mechanistic Insights and Clinical Implications"

Monday, December 7, 2020
Ron Rapini, M.D.
The University of Texas MD Anderson Cancer Center
"Derma Tips"

Monday, December 14, 2020
Edmund S. Cibas, M.D.
Harvard Medical School

"Personal Best: Dashboards for Performance Improvement in Cytology"

Monday, January 11, 2021
Sankha (Bobby) Basu, M.D., Ph.D.
Harvard Medical School
"A Need for Speed: Accelerating Pathology Using Rapid Mass Spectrometry-Based Platforms"

Monday, January 25, 2021
Svasti Haricharan, Ph.D.
Sanford Burnham Prebys Medical Discovery Institute
"Non-repair Activities of DNA Repair Proteins in Treatment Resistance and Cancer Progression"

Monday, February 1, 2021
Jason L. Hornick, M.D., Ph.D.
Harvard Medical School
"The 2020 WHO Classification of Soft Tissue Tumors: What's New?"

Monday, February 8, 2021
Amir Zarrinpar, M.D., Ph.D.
UC San Diego
"The Microbiome and Time: Understanding the Cyclical Dynamics of Microbiome on Host Metabolism"

Monday, February 22, 2021
Ellen F. Foxman, M.D., Ph.D.
Yale School of Medicine
"Uncovering Natural Defenses in the Fight Against Respiratory Viruses"

Monday, March 1, 2021
Jianzhu Chen, Ph.D.
Massachusetts Institute of Technology
"Targeting Macrophages in Disease Intervention"

Monday, March 8, 2021
Dmitry Gabrilovich, M.D., Ph.D.
"Myeloid-Derived Suppressor Cells in Regulation of Tumor Progression"

Monday, March 15, 2021
David Cheresh, Ph.D.
UC San Diego Dept. of Pathology
"Cancer Stem Cells and Their Role in Drug Resistance"

Monday, March 22, 2021
Prashant Mali, Ph.D.
UC San Diego Dept. of Bioengineering
"Programmable Tools for DNA, RNA and Protein Targeting: New Approaches, New Challenges"

Monday, March 29, 2021
Asa Gustafsson, Ph.D.
UC San Diego School of Pharmacy / Pharmaceutical Sciences
"Novel Mechanisms of Mitochondrial Quality Control in the Heart"

Monday, April 5, 2021
John Hart, M.D.
University of Chicago Medicine
"Non-Alcoholic Steatohepatitis: A Surgical Pathologist's Perspective"

Monday, April 12, 2021 - 12:00pm PDT
Ron Heeren, Ph.D.
Maastricht University, The Netherlands
"Translation Molecular Pathology: Imaging Across Boundaries"
Monday, April 19, 2021
Cole Ferguson, M.D., Ph.D.
UC San Diego Dept. of Pathology
"Ubiquitin Signaling in the Regulation of Chromatin During Neurodevelopment"

Monday, April 26, 2021
Olivier Harismendy, Ph.D.
UC San Diego Dept. of Medicine
"The Breast Pre-Cancer Atlas Illustrates the Molecular and Micro-Environmental Diversity of Ductal Carcinoma in Situ"

Monday, May 10, 2021
Genhong Cheng, Ph.D.
UC Los Angeles
"Innate Immune and Antibody Responses against COVID-19"
Monday, May 17, 2021
Malay Haldar, M.D., Ph.D.
University of Pennsylvania Perelmen School of Medicine
"Macrophages and Dendritic Cells in the Tumor Microenvironment"
Monday, May 24, 2021
Geetu Tuteja, Ph.D.
Iowa State University
"Using-Omics Based Approaches to Identify Key Regulators of Placental Development"


Monday, September 9, 2019
Steven L. Gonias, M.D., Ph.D.
UCSD - Department of Pathology
"Exploiting the Fibrinolysis System to Regulate Innate Immunity"

Monday, September 16, 2019
Olga Danilova, M.D., Ph.D.
VA Portland Health Care System
"Prognostic Markers in Diffuse Large B-Cell Lymphoma"

Monday, September 23, 2019
Shizhen (Emily) Wang, Ph.D.
UCSD - Department of Pathology
"Cancer-Secreted Extracellular Vesicles in Metastasis"

Monday, September 30, 2019
Jay Desgrosellier, Ph.D.
UCSD - Department of Pathology
"Suppressing Stemness to Combat Aggressive Breast Cancers"

Monday, October 7, 2019
Maria T. Diaz-Maco, Ph.D.
Sanford Burnham Presby's Medical Discovery Institute
"Metabolic Reprogramming in Neuroendocrine Prostate Cancer"

Monday, October 14, 2019
Mahmoud A. Khalifa, M.D., Ph.D.
University of Minnesota
"Can an Endometrial Sample Tell Us More Than the Cell Type and Grade of a Tumor?"

Monday, October 21, 2019
Jerad M. Gardner, M.D.
University of Arkansas for Medical Sciences
"How Twitter and Facebook Changed My Life: The Role of Social Media in Pathology and Medicine"

Monday, October 28, 2019
Peter Yingxiao Wang, Ph.D.
UCSD - Department of Bioengineering
"Live Cell Imaging and ImmunoEngineering for Cancer Immunotherapy"

Monday, November 4, 2019
C. Savio Chan, Ph.D.
Northwestern University
"Neuronal Diversity in the Basal Ganglia – Bidirectional Motor Control by Pallidal Neuron Subtypres"

Monday, November 18, 2019
Gerald S. Shadel, Ph.D.
Salk Institute
"Mitochondrial Stress Signaling in Disease, Aging and Immunity"

Monday, December 2, 2019
Bernd Schnabl, M.D.
UCSD - Department of Medicine
"Translating Microbiota Research Into Therapies for Liver Disease"

Monday, December 9, 2019
Alice Soragni, Ph.D.
UCLA - Division of Hematology-Oncology
"Sarcoma Patient-Derived Tumor Organoids for Personalized Medicine Applications"

Monday, January 6, 2020
Gerald Berry, M.D.
Stanford University Medical Center
"Giant Cell Arteritis/Aortitis: Current Concepts - Pathology and Pathogenesis"

Monday, January 13, 2020
Jinsong Liu, M.D., Ph.D.
University of Texas MD Anderson
"The Tumor Origin and Therapeutic Resistance: Insight from Polyploid Giant Cancer Cells"

Monday, January 27, 2020
Sean Bendall, Ph.D.
Stanford University, School of Medicine
"Massively Multiplexed Imaging of Human Pathology"

Monday, February 3, 2020
Livia Eberlin, Ph.D.
University of Texas at Austin
"Ambient Mass Spectrometry for Cancer Diagnosis and Clinical Use"

Monday, February 10, 2020
Genhong Cheng, Ph.D.
UC Los Angeles
"Regulation of Infection, Inflammation and Metabolism by Type I Interferon-Mediated Innate Immune Response"

Monday, February 24, 2020
Farnaz Hasteh, M.D. & Somaye Zare, M.D.
UC San Diego Department of Pathology
"Intraoperative Assessment of Pelvic Lesions in Female Patients: An Interactive Approach Using Cytology and Frozen Section Slides"

Monday, March 2, 2020
Monica Guma, M.D., Ph.D.
UC San Diego Department of Medicine
"Talk Title TBA"

Monday, March 9, 2020
Alan R. Saltiel, Ph.D.
UC San Diego Department of Medicine and Pharmacology
"Inflammation and the Regulation of Energy Homeostasis"

Monday, May 11
Tiffany Tanaka, M.D.
UC San Diego Department of Medicine
“Immune Dysfunction in Myelodysplastic Syndromes”

Monday, May 18
Oluwole Fadare, M.D.
UC San Diego Department of Pathology
"Molecular Subclassification of Endometrial Carcinoma: Promise and Limitations"

Monday, May 25 - Memorial Day - NO PRLS THIS WEEK

Monday, June 1
Michael Kalichman, Ph.D.
UC San Diego Department of Pathology
"Fostering Integrity in Science"

Monday, June 8
Sarah S. Murray, Ph.D., FACMG
UC San Diego Department of Pathology
“Clinical Genomics and Cytogenomics Testing for Cardiomyopathies and Arrhythmias”

Monday, June 15 - NO PRLS THIS WEEK

Monday, June 22
Ruth S Waterman, M.D., MS
UC San Diego Department of Anesthesiology
“Pharmacogenomics and Precision Medicine: The Future or Fantasy?"

Monday, June 29
Anne Hiniker, M.D., Ph.D.
UC San Diego Department of Pathology
"LRRK2 in Parkinson's Disease"

Monday, July 6
Yimin Zou, Ph.D.
UC San Diego Department of Medicine
"Cell Polarity Signaling Pathways in Glutamatergic Synapse Formation and Maintenance"

Monday, July 13 - NO PRLS THIS WEEK

Monday, July 20
Erin Thorpe, MS, CHC, LGC
Illumina Clinical Services Laboratory, Illumina Inc., 
Marilyn Jones, M.D.
Rady Children’s Hospital, San Diego
“An iHope Partnership  Spotlight: the Hospital Infantil de Las Californias”

Monday, July 27
Grace Lin, M.D., Ph.D.
UC San Diego Department of Pathology
"Pulmonary and Cardiac Findings in COVID-19 Autopsies Performed at UCSD and Review of the Literature"

Monday, August 3
David T. Pride, M.D., PhD.
UC San Diego Department of Pathology
"UC San Diego Health's Response to Sars-CoV-2 Testing"


September 10
Gen-Sheng Feng, Ph.D.
UCSD - Department of Pathology
"Deciphering the Anti-Oncogenic Effects of Classical Oncoproteins in Liver Cancer"

September 17
Mojgan Hosseini, M.D.
UCSD - Department of Pathology
"Hepatitis A outbreak in San Diego County, 2016-2017: A morphologic and epidemiologic review"

September 24
Shi-Yuan Cheng, Ph.D.
Neurology-Northwestern University
"Autophagy in Glioblastoma, Critical for Tumorigenicity and Viable Target for Combination Therapy"

October 1
Dong-Er Zhang, Ph.D.
UCSD - Department of Pathology
"Post-Translational Modification by an Ubiquitin-like Protein ISG15 in Immune Responses and Cancer"

October 8
R. Luke Wiseman, Ph.D.
The Scripps Research Institute
"Unexpected Outcomes: Non-secretory Functions of the Unfolded Protein Response"

October 15
Harold Hoffman, M.D., Ph.D.
UCSD - Department of Pediatrics
"The Inflammasome and Human Disease"

October 22
David T. Pride, M.D., Ph.D.
UCSD - Department of Pathology
"Ecology of Viruses in the Human Virome"

October 29
Donald Cleveland, Ph.D.
UCSD - Department of Cellular Molecular Medicine
"From Charcot to Lou Gehrig: Mechanism and Therapy in ALS"

November 5
Peter P. Lee, M.D.
Immuno-Oncology - City of Hope
"Complexities of the Tumor Microenvironment and Lymph Nodes"

November 26
Richard Daneman, Ph.D.
UCSD - Department of Pharmocology
"Regulation of the Blood-Brain Barrier in Health and Disease"

December 3
J. Silvio Gutkind, Ph.D.
UCSD - Department of Pharmocology
"Gut-in-a-dish Model to Develop Personalized Therapies for Chronic Inflammatory Diseases"

December 13
Channing J Der, Ph.D.
University of North Carolina at Chapel Hill—Lineberger Comprehensive Cancer
"Drugging Undruggable RAS for Cancer Treatment"

January 7
Sharon L. Reed, M.D., M.S.s.C.T.M, D.(A.B.M.M.)
UCSD - Department of Pathology
"Challenges of Bench to Bedside: Clinical Trial for a Repurposed Drug for GI Protozoa"

January 10
Ceshi Chen, M.D.
Kunming Institute of Zoology - China
"KLF5 Transcription Factor Promotes Breast Stemness and Malignancy"

January 14
Peter Ernst, D.V.M., Ph.D.
UCSD - Department of Pathology
"COnsideration for the Role of Evolution in Interpreting Animal Models of Inflammatory Bowel Disease"

January 28
Manuela Raffatellu, M.D.
UCSD - Department of Pediatrics
"Evasion of IL-22-Mediated Antimicrobial Responses by Bacterial Pathogens"

February 4
Adebowale J. Adeniran, M.D.
Yale University - Department of Pathology
"Update on Molecular Testing for Cytologically Interdeterminate Thyroid Nodules"

February 11
Ellen C. Breen, Ph.D.
UCSD - Department of Medicine
"The Role of Skeletal Muscle Microvasculature In Exercise. Implications for Chronic Obstructive Pulmonary Disease"

February 25
X.J. Meng, M.D.
Virginia-Maryland College of Veterinary Medicine
"The Ever-Expanding Host Range and Cross-Species Infection of Hepatitis E Virus"

March 4
Lea Grinberg
"Rewriting the Initial Stages of Alzheimer's Disease: The Role of Neuromodulatory Systems in Pre-Cognitive Symptoms and Disease Pathogenesis"

March 11
Elina Zuniga, Ph.D.
UCSD - Department of Molecular Biology
"Immune Adaptations During Chronic Viral Infection"

March 18
Lee Zhou, Ph.D.
Harvard Medical School - Division of Biological Sciences
"The ATR Signaling Circuitry: From Basic Research to Targeted Cancer Therapy"

March 25
Robert Hevner, M.D., Ph.D.
UCSD - Department of Pathology
"Death, Fate, and Transcription in Cerebral Cortex Neurogenesis"

April 1
Huan-You Wang, M.D., Ph.D.
UCSD - Department of Pathology
"Richter Transformation: Then and Now"

April 8
Alexis C. Komor, Ph.D.
UCSD - Department of Chemistry and Biochemistry
"Base Editing: Performing Chemistry on the Genome"

April 15
Stephanie Eisenbarth, M.D., Ph.D.
Yale University
"A Unique T Cell Drives Anaphylactic IgE"

April 22
Diane Shelton, D.V.M., Ph.D.
UCSD - Department of Pathology
"A Mitochondrial Transporter SLC25A12 Gene Mutation Shows a Strong Association with Inflammatory Myoptahy in a Family of Dutch Shepherd Dogs"

April 29
Denise Malicki, M.D., Ph.D.
UCSD - Department of Pathology
"How to Use Pathology to Understand Your Study Results"

May 6
Jacqueline Payton, M.D., Ph.D.
Washington University School of Medicine
"Discovery Epigenetics Drive Precision Medicine Approaches for Lymphoma"

May 13
Sanjay Nigam, M.D.
UCSD - Department of Pediatrics
"Rewriting the Story of Drug Transport and Metabolism According to Biology"

May 20
Frank Furnari, Ph.D.
UCSD - Department of Pathology
"Leveraging PTEN Nuclear Function for Therapeutic Intervention in Glioma"

June 3
Patricia Gnieslaw de Oliviera, Ph.D.
UCSD - Department of Medicine - Rheumatology, Allergy and Immunology
"The Role of Sialic Acids in Rheumatoid Arthritis Fibroblasts-Like Synoviocytes (FLS)"


Meghan O. Altman, Ph.D.
UCSD - Department of Pathology
"Can We Forecast the Next Major H1N1 Influenza Strain?"

June 10
Vanessa Goodwill, M.D.
UCSD - Department of Pathology
"Novel Retinal Protein Aggregates in Patients with Sporadic Creuzfeldt-Jakob Disease and Chronic Traumatic Encephalopathy"


Nazia Abbasi, Ph.D.
UCSD - Department of Pathology
"DDX5-Dependent RNA Programs Promote Tuft Cell Specification, Colitis, and Intestinal Tumorigenesis"

June 17
Jin Lee, Ph.D.
UCSD - Department of Pathology
"Preventative Inhibition of Liver Cancer by Systematic Activation of Innate Immunity"


Nicholas Coley, M.D., Ph.D.
UCSD - Department of Pathology
"Uveal Melanoma: Interpreting Discordant Monosomy 3 Fish/Microarray Results and the Role of BAP1"

June 24
Christina N. Alarcon, D.V.M., D.A.C.V.P.
UCSD - Department of Pathology
"Enucleated Cells as Therapeutic Agents"


David Castillejos
UCSD - Department of Pathology
"Non-invasive Ocular Imaging Reveals Neural Dysfunction in a Mouse Model of Tauopathy"


September 11
Steven Gonias, MD, PhD
UCSD – Department of Pathology
"The Fibrinolysis System in Innate Immunity and the Response to Injury"

September 14 (Thurs, 12PM-1PM)
Yvonne Eisele, PhD
Scripps Research Institute – Department of Molecular Medicine
"Discovery and Characterization of Pathogenic Transthyretin (TTR) Oligomers in Amyloid Disorders"

September 18
Chengbiao Wu, PhD
UCSD - Department of Neurosciences
"Axonal Dysfunction: an Early Cellular Pathology Underlying Neurodegeneration"

September 25
Guo-Min Li, PhD
University of Texas Southwestern – Department of Radiation Oncology
"DNA mismatch repair in cancer susceptibility and therapy"

September 28 (Thurs, 12PM-1PM, CNCB)
Xu Chen, PhD
UC San Francisco – Gladstone Institute of Neurological Diseases
" Role of p300 in Tau Pathogenesis: Acetylation, Autophagy and Metabolic Connection"

October 2
Shizhen (Emily) Wang, PhD
UCSD – Department of Pathology
"Local and systemic effects of cancer: role of extracellular miRNAs"

October 9
Demetrios Braddock, MD, PhD
Yale University – Department of Pathology

October 16
Jesse Dixon, MD, PhD
Salk Institute – Helmsley-Salk Fellow
"Identifying 3D chromatin structural alterations in cancer genomes"

October 23
Seema Aceves, MD, PhD
UCSD – Department of Pediatrics
"Eosinophilic Esophagitis- "Mechanisms and Impacts of Tissue Remodeling"

October 30
Farnaz Hasteh, MD
UCSD – Department of Pathology
"Discrepancies and Errors in Cytology Cases with Emphasis on Recognizing the Sources of Errors: an Interactive Approach to Prevent Mistakes"

November 6
Nicola Allen, PhD
Salk Institute – Laboratory of Molecular Neurobiology
"Astrocyte regulation of neuronal function"

November 13
Howard Feldman, MD, FRCP(C)
UCSD – Department of Neurosciences
"Therapeutic Progress in Alzheimer’s Disease: Recharting Course"

December 4
Jonathan Lin, MD, PhD
UCSD – Department of Pathology
"Genetic Variation of Protein Quality Control in Human Disease"

January 8
Jerold Chun, MD, PhD
Sanford Burnham Prebys – Department of Neuroscience
“Genomic Mosaicism in the Normal and Diseased Brain”

January 22
Ardem Patapoutian, PhD
Scripps - Department of Neurosciences
“Ion Channels that Feel the Force”

January 29
Adriana Tremoulet, MD
UCSD – Department of Pediatrics
“New Therapies to Put Out the Inflammatory Fire in Kawasaki Disease ”

February 5
Teri A. Longacre, MD
Stanford – Department of Pathology
“Uterine Mesenchymal Neoplasms: New Developments”

February 12
Chisato Shimizu, MD
UCSD – Department of Pediatrics
“How Genetic Analysis Might Lead Us to the Antigenic Trigger for Kawasaki Disease”

February 26
David Dimmock, MD
Rady’s Children’s Hospital – Department of Genomic Medicine
“Clinical Rapid Genome Wide Sequencing of Infants and Children: Implementation, Safety and Effectiveness"

March 5
Soumet Paul, PhD
University of Kansas – Department of Pathology
“Transcriptional Control of Trophoblast Progenitors and Placentation”

March 12
Jin Zhang, PhD
UCSD – Department of Pharmacology
“Illuminating the Biochemical Activity Architecture of the Cell”

March 19
Nieng Yan,PhD
Princeton University - Shirley Tilghman Professor of Molecular Biology
“Seeing is Believing: Structure and Functions of Molecules in Glucose Uptake”

March 26
Scott W. Binder, MD
UCLA – Department of Pathology

April 2
Wendy Huang, PhD
UCSD – Department of Cellular and Molecular Medicine
“RNA Binding Proteins in Mucosal Biology”

April 9
Ronald McLawhon, MD, PhD, FCAP
UCSD – Department of Pathology
"Pathology Moneyball: The Art of Winning at an Unfair Game A Hitchhiker’s Guide to Coding, Payment Systems and Policies, and
Healthcare Reform"


September 12
David Cheresh, PhD
UCSD – Department of Pathology
“Targeting KRAS Addiction, Cancer Stemness and Drug Resistance in Epithelial Tumors”

September 19
John Kim Choi, MD, PhD
St. Jude Children’s Research Hospital
“Regulation of B cell Proliferation by E2A/TCF3”

September 26
Victoria Stepanova, PhD
University of Pennsylvania Medical School
“Novel Functions of Urokinase-type Plasminogen Activator (uPA) In the Nucleus”

October 3
Reuben Shaw, PhD
The Salk Institute
“The AMPK Pathway: Metabolic Rewiring Under Stress & Therapeutic Implications”

October 10
Donna Hansel, MD, PhD
UCSD – Department of Pathology
“mTOR Signaling in Bladder Cancer Progression”

October 17
David Natale, PhD
UCSD – Department of Reproductive Medicine
“Investigating Mechanisms Underlying Placenta Insufficiency In the Mouse”

October 24
Terry Hwa, PhD
UCSD – Department of Physics
“A Top-down Approach Towards Predictive Biology”

October 31
Nathan Lewis, PhD
UCSD – Department of Pediatrics
“Comprehensive Computational Models of Tumor-specific Metabolism: Capabilities, Considerations, Pitfalls, and Potential”

November 7
Dihu Yu, MD, PhD
MD Anderson Cancer Center
“Tackling Imposing Challenges in “'Cancer Moonshot'”

November 14
Pascal Gagneux, PhD
UCSD – Departments of Pathology
“Glycan Evolution and Infection – Patterns in the Glycan Jungle”

November 28
Kung-Liang Guan, PhD
UCSD – Department of Pharmacology
“The Hippo Pathway in Cell Growth, Tissue Homeostasis, and Cancer”

December 5
Karsten Zengler, PhD
UCSD – Department of Pediatrics
“Elucidating the Role of the Microbiome in Human Disease”

January 9
Kevin Shannon, MD
UC San Francisco – Department of Pediatrics
“Targeting Aberrant Ras Signaling in Cancer”

January 23
Wendy Frankel, MD
Ohio State University Department of Pathology
“Mismatch Repair Deficient Colorectal Carcinoma and Lynch Syndrome”

January 30
Rob Knight, PhD
UCSD – Department of Pediatrics
“The Human Microbiome in Health and Disease”

February 6
Ze’ve Ronai, PhD
Sanford Burnham Prebys Medical Discovery Institute
“Linking the Microbiome and Immune Checkpoint by the Ubiquitin Ligase RNF5”

February 27
Mark Valasek, MD, PhD
UCSD – Department of Pathology
“Stomach Bugs and Jelly Bellies: Anatomic Pathology as a Foundation of Personalized Medicine”

March 6
Mark H. Kaplan, PhD
Indiana State University – Departments of Pediatrics, and Microbiology and Immunology
“Development and Function of Il-9-secreting T Cells”

March 13
Richard C. Friedberg, MD, PhD, FCAP, MHCM, CPE
University of Massachusetts Medical School-Baystate – Department of Pathology
“Advancing and Securing the Future of Pathology”

March 20
Erkki Ruoslahti, MD, PhD
Sanford Burnham Prebys Medical Discovery Institute
“Disease-specific Molecular Markers in Blood Vessels: Target Molecules for Drug Delivery”

March 27
Isaac Pessah, PhD
UC, Davis – Department of Molecular Biosciences
“What’s Hot in Malignant Hyperthermia”

April 3
Wei Wang, PhD
UCSD - Department of Chemistry and Biochemistry
UCSD - Department of Cellular and Molecular Medicine
“Genomics, epigenomics and precision medicine”

April 10
Gabriel Haddad, MD
UCSD – Department of Pediatrics
“Genetic Mechanisms of Human Adaptation at High Altitude: An Experiment in Nature”

April 17
Jeff Neul, MD, PhD
UCSD – Department of Neuroscience
“Rett Syndrome: Genetics, Pathophysiology, and Approaches to Treatment”

April 24
Alfredo Molinolo, MD, PhD
UCSD – Department of Pathology
"Rare Bone Disease: The FGF23 Story"

May 1
John Chang, MD
UCSD_ Department of Medicine
"Diversifying T Lymphocyte Fates during Adaptive Immunity Against Microbial Pathogens"

May 8
John Thorson, MD, PhD
UCSD – Department of Pathology
"Clinical Next Generation Sequencing – The Journey and the Experience"

May 15
Kun Zhang, PhD
UCSD – Department of Bioengineering
"Analysis of DNA Methylation Haplotypes in
Human Stem Cells and Cancer"

May 22
Peter Humphrey, MD, PhD
Yale University – Department of Pathology
"High-grade Prostate Cancer: Clinico-pathologic and Molecular Aspects"

June 5
Maricel Gozo, PhD
Cheresh Lab – Departments of Pathology
"Integrin β3, a Stress Response Gene Driving Stress Tolerance in Epithelial Cancer"
Francesca Soncin, PhD
Parast Lab – Department of Pathology
"Human Placental Development: What the Mouse Can (Not) Tell Us"

June 12
Richard Wong, MD
PGY-4 – Department of Pathology
"Type 2 Innate like Lymphocytes (ILC2) in a Patient with Hypereosinophilic Syndrome"
Stephen Searles
Bui Lab – Department of Pathology
"Cell-cell Fusion as a Mechanism of DNA Exchange in Cancer"

June 19
Zeljko Dvanajscak, MD
PGY-2 – Department of Pathology
"Thrombotic Microangiopathy and IgA- dominate Immune Complex-mediated Renal Injury Following Chemotherapy:
A Novel Association?"
Amritha Balakrishnan
Morris Lab – Department of Pathology
"Analysis of T Cell Responses in Chronic Graft versus Host Disease by Single Cell Sequencing"

June 26
Heike Kroeger, PhD
Lin Lab – Department of Pathology
"Small Molecule ATF6 Activators Differentiate hESCs/hiPSCs Into Vascular Endothelium"
David Carr, MD
PGY-2 – Department of Pathology
"Epidemiologic Evaluation of Biopsies Performed for Potential Gastrointestinal Graft-versus-host disease"


September 14
Tom Lane, M.D.
UCSD Pathology Emeritus
"Targeted Cellular Immunotherapy for AML: A Genomic Approach"

September 21
Mark Cookson, Ph.D.
National Institute on Aging
"Pathways to Parkinsonism"

September 28
Henry Powell, M.D.
UCSD – Pathology
"Fabric, Form, Dyes and the Evolution of Histology"

October 5
Daniel Geschwind, M.D.
UCLA – Department of Neurology
"How Genetic and Genomic Studies Inform the Neurobiology of Autism Spectrum Disorder"

October 12
Susan S. Taylor, Ph.D.
UCSD – Chemistry & Biochemistry
"Dysfunctional PKA Drives Diverse Disease Phenotypes"

October 19
Laura Crotty Alexander, M.D.
UCSD - Veterans Administration San Diego
"E-cigarettes: a Road to Health and Happiness? Or a Road to a New Generation of Nicotine Addicts and Lung Disease"

October 26
Pradipta Ghosh, M.D.
UCSD - Medicine
"How to Reset a Diseased Cell"

November 2
Richard Finn, M.D.
UCLA - Department of Medicine
"Translating Advances in Molecular Therapies from Oncology into HCC"

November 9
Anthony O’Donoghue, Ph.D.
UCSD - Skaggs School of Pharmacy
“Global and Unbiased Detection of Proteolytic Activity in Infectious Organisms: A Rapid Approach to Identify Key Proteases for Drug Development”

November 16
Fumhiko Urano, M.D., Ph.D.
Washington University
"Etiology, Diagnosis, and Treatment of Wolfram Syndrome, a Prototype of Human ER Stress Disorder"

November 30
Ruth Patterson, Ph.D.
UCSD – Family Medicine & Public Health
"Intermittent Fasting and Metabolic Health"

December 7
Mamata Sivagnanam, M.D.
UCSD – Pediatrics
"Tufting Enteropathy: Lessons from a Rare Disease"

December 14
Shane Crotty, Ph.D.
UCSD – Allergy & Immunology
"Designing Vaccines: Differentiation and Function of T Follicular Helper (Tfh) Cells"

January 11
Christopher K. Glass, MD, PhD
UCSD –Department of Cellular & Molecular Medicine
“Exploring What Macrophages are ‘Thinking’ in Health and Disease”

January 25
Gerald Morris, MD, PhD
UCSD- Department of Pathology
“Dual Receptor T Lymphocytes as Selective Mediators of Post-Transplant Immune Responses”

February 1
Hanna Mikkola, MD, PhD
UCLA- Department of Molecular, Cell & Developmental Biology
“Uncovering the Path to Blood Stem Cells”

February 8
Paul E. Wakely, Jr., MD
Ohio State University-Department of Pathology
“Soft Tissue Cytopathology: The OSU Experience”

February 22
Jay Desgrosellier, PhD
UCSD-Department of Pathology
“Harnessing Insight from Mammary Stem Cells to Combat Aggressive Breast Cancers”

February 29

March 7
Eyal Raz, MD
UCSD-Department of Medicine
“Novel Insight in the Pathogenesis of Immune-Mediated Asthma: Implications for New Therapy”

March 14
Mark Fuster, MD
UCSD – Department of Medicine
“Modifying the Immune Landscape in Lung Cancer”

March 21
Nissi Varki, MD
UCSD – Department of Pathology
“Caveats in the Interpretation of Models of Human Disease”

March 28
Alexandra Newton, PhD
UCSD – Department of Pharmacology
“Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor”

April 4
Richard Gallo, MD, PhD
UCSD –Department of Dermatology
“Skin is an Immunological Superorganisim”

April 11
Mark Tuszynski, MD, PhD
UCSD – Department of Neuroscience
“Growth Factor Gene Therapy for Alzheimer’s Disease”

April 18
Dianne McKay, MD
UCSD – Department of Medicine
“Role of Innate Immunity in Ischemic Renal Injury; Focus on Kidney Transplantation”

April 25
Subhojit Roy, MD, PhD
UCSD – Department of Pathology
“Neuronal Trafficking in Physiology and Disease”

May 2
Lindsey A. Miles, PhD
Scripps Research Institute
“Plasminogen Receptor, Plg-Rkt, a Novel Regulator of Mammary Health Disease”

May 9
William J. Sandborn, MD
UCSD – IBD Center
“IBD and Pathology: Treating to Mucosal Healing and Dysplasia Surveillance”

May 16
Richard Scheuermann, PhD
J. Craig Venter Institute
“Development and Application of Computational Methods For Analysis of Flow and Mass Cytometry Data”

May 23
Christina Jamieson, PhD
UCSD - Moores Cancer Center
“The Bone Niche and Therapy Resistance in Bone Metastatic Prostate Cancer”

June 6
Francesca Soncin, PhD
UCSD - Pathology (Parast Lab)
“Human Placental Development: What the Mouse Can (Not) Tell Us”
Anne Phan, PhD
UCSD - Cellular Molecular Medicine (Esko Lab)
“Heparan Sulfate in Wound Repair and Regeneration”

June 13
Jorge Benitez, PhD
UCSD - Ludwig Cancer Research (Furnari Lab)
“PTEN Regulates Glioblastoma Oncogenesis Through Chromatin-associated Complex of DAXX and Histone H3.3.”
Xiaolin Luo, PhD
UCSD - Pathology (Feng Lab)
“A New Model for NAFLD, NASH to HCC”

June 20
Xiaoyan Liao, MD, PhD
UCSD - AP Pathology
“Evaluating the Immunodetection of CMV in Gastrointestinal Biopsies: Clinical Pathological Correlations”
James Solomon, MD
UCSD - AP Pathology
“Her2/neu Testing in Breast Cancer: Comparative Analysis of In Situ Hybridization and Immunohistochemistry in a Dual-Testing System”

June 27
Ciro Zanca, PhD
UCSD - Ludwig Cancer Research (Furnari Lab)
“Tumor Heterogeneity Contributes to Resistance to Anti-EGFR Therapy in Glioblastoma”
Ling Wang, MD
UCSD - Pathology (Hematopathology Fellow)
“Keratin Positive Lymphoma: A Diagnostic Pitfall”


September 8
Scott M. Lippman, M.D.
Director, UCSD Moores Cancer Center
“Targeting Genetic Drivers in Premalignancy”

September 15
Steven L. Gonias, M.D., Ph.D.
Distinguished Professor and Chair, UCSD Pathology
“Protease Receptors – Coping with a Stressful Environment”

September 22
Frank Zhao, M.D., Ph.D.
Professor, UCSD Pathology
“Signal Transducers Meet Check Points in Malignant Lymphomas”

September 29
Richard L. Klemke, Ph.D.
Professor, UCSD Pathology
“Fingerprinting Invasive Membrane Protrusions Reveals Metastatic Culprits”

October 6
Ya-Huei Kuo, Ph.D.
City of Hope
“Targeting Leukemia Stem Cells: Clues from Molecular Mechanism”

October 13
Alessandra Franco, M.D., Ph.D.
UCSD Pediatrics
“Specificity of Regulatory T Cells that Modulate Vascular Inflammation: A New Mechanism for Intravenous Immunoglobulin (IVIG) Therapy”

October 20
Ariel Feldstein, M.D.
UCSD Rady’s Children’s Hospital
“From NAFLD to NASH to Cirrhosis-New Insights into Disease Mechanisms”

October 27
Menno van Lookeren Campagne, Ph.D.
Genentech, Inc.
“Understanding Crohn’s Disease Through Genetics”

November 3
Adam J. Engler, Ph.D.
UCSD Bioengineering
“Cytoskeletal Remodeling Modulates Cardiomyocyte Contractile Function During Aging”

November 10
Gen-Sheng Feng, Ph.D.
UCSD Pathology
“The Anti-Oncogenic Effects of Pro-Oncogenic Molecules in Liver Cancer”

November 17
Radha Ayyagari, Ph.D.
UCSD Ophthalmology and Pathology
“Understanding the Molecular Basis of Retinal Degeneration by Next Generation Sequencing”

December 1
Xin Wei Wang, Ph.D.
National Cancer Institute
“The Biological and Clinical Challenge of Liver Cancer Heterogeneity”

December 8
Yury Miller, M.D., Ph.D.
UCSD Medicine
“Lipid Abnormalities and Atherosclerosis: The Zebrafish Perspective”

January 12
Jeffrey D. Esko Ph.D.
UCSD Cellular and Molecular Medicine
"Proteoglycan Mediated Lipoprotein Metabolism"

January 26
Paul S. Mischel, M.D.
UCSD Pathology & Ludwig Institute for Cancer Research
"EGFR and Metabolic Reprogramming in Cancer"

February 2
Jack Dixon, Ph.D.
UCSD Cellular and Molecular Medicine
"A New Family of Kinases that Plays Important Roles in Human Health"

February 9
Philip H. Howe, Ph.D.
Medical University of South Carolina
"Transforming Growth Factor Beta-Mediated Epithelial-Mesechymal Transition"

February 18 (Special Guest Speaker)
Stewart Sell, M.D.
University of Albany, SUNY
"Immunopathology of Experimental Models of Syphilis, Influenza and Asthma"

February 23
Farhad Imam, M.D. Ph.D.
UCSD Pediatric
"Insights into Neonatal Hypoxic Injury from a Zebrafish Developmental Genetic Model"

March 2
G. Diane Shelton, D.V.M., Ph.D.
UCSD Pathology
"Choosing the Best Animal Model for Preclinical Therapeutic Trials in Human Muscle Disease"

March 9
Karen Pierce, Ph.D.
UCSD Autism Center
"Advances in Biomarker Discovery in Autism"

March 16
Lawrence S. Prince, M.D., Ph.D.
UCSD Pediatrics
"Molecular Mechanisms Linking Inflammation and Abnormal Lung Development"

March 23
Napoleon Ferrara, M.D.
UCSD Pathology & Moores Cancer Center
"Anti-Angiogenic Therapy of Tumors: New Insights"

March 30
Julie Baker., Ph.D.
Stanford University
"Endogenous Retroviruses and Endoreplication in the Placenta"

April 6
Alec Zhang, Ph.D.
University of Texas Southwestern
"ITIM Receptors-Surprising Roles In Acute Leukemia Development"

April 13
Dorothy Sears, Ph.D.
UCSD - Endocrinology
“Novel Diet & Behavioral Interventions for Reducing Type 2 Diabetes & Cancer Risk”

April 20
Nicole Baumgarth, D.V.M., Ph.D.
University of California, Davis
“Borrelia Burgdorferi Suppresses Long-term Immunity”

April 27
Sanjay Nigam, M.D.
UCSD - Pediatrics
“Drug Transporters, Metabolism and Disease”

May 4
Jeffrey A. Golden, M.D.
Harvard Medical School
“Genetic and Metabolic Pathways to Interneuron Disorders”

May 11
Frank La Ferla, Ph.D.
University of California, Irvine
“Translational Challenges of Mouse Models in Alzheimer’s Disease”

May 18
LoAnn Peterson, M.D.
Northwestern Memorial Hospital
“Large Granular Lymphocyte Leukemia – What Have We Learned?”

June 1
Lynette Corbeil, D.V.M., Ph.D.
UCSD Pathology
“Lessons from Cows: Pathogenesis of Pneumonia”

June 8
Xiaoyan Liao, M.D. - PGY-2 AP/CP
UCSD – Pathology
“Maternal Obesity Exacerbates the Extent and Severity of Chronic Villitis in the Term Placenta”
Coralie Brifault, Ph.D.
Gonias Lab/UCSD - Pathology
“LRP1 and Innate Immunity”

June 15
Brett Lowenthal, M.D. - PGY-3 AP/CP
UCSD – Pathology
“Fine Needle Aspiration Diagnoses: A Retrospective Quality Assurance Study”
Philip Gordts, Ph.D.
Esko Lab /UCSD - Cellular & Molecular Medicine
“Mechanisms of Triglyceride Lowering with APOC3 Knockdown”

June 22
Jerry Chiang, Ph.D.
Lin’s Lab/UCSD - Pathology
“Endoplasmic Reticulum Stress in Retinal Degeneration”
James Solomon, M.D. - PGY-2 AP/CP
UCSD - Pathology
“Targeted Next Generation Sequencing of Uveal Melanoma Reveals Mutually Exclusive GNAQ and GNA11 Mutations”

June 29
Steve Searles, B.A.
Graduate Student, Bui Lab - Pathology
“Exploring the Immunemodulatory Potential of Tumor-derived Exosomes and Exosomal Proteins”
Miriam Cohen, Ph.D.
Gagneux Lab/UCSD – Cellular & Molecular Medicine
“Virus and Mucins – A Sticky Story”


September 9
Sanford Barsky, M.D.
University of Nevada Cancer Institute
“Tumor Embolus – Blastocyst Connection: Is it the Rainbow Connection?”

September 16
Greg Daniels, M.D., Ph.D.
UC San Diego Moores Cancer Center
“Solid Tumor Immune Response: Frenemies”

September 23
David Herold, M.D., Ph.D., D.A.B.C.C.
UC San Diego Pathology
“Mass Spectrometry – Applications to the Clinical Laboratory of the Future”

October 7
Randy Gascoyne, M.D.
British Columbia Cancer Agency
“Hodgkin Lymphoma: From Discovery to Clinical Translation”

October 14
Jeff Goldberg, M.D., Ph.D.
UC San Diego Ophthalmology
“Stem Cells for Ophthalmology: A Molecular Pathway to Glaucoma Cell Therapy”

October 21
Hooman Rashidi, M.D.
Santa Barbara Cottage Hospital
“Diagnostic Utility of Flow Cytometry on Peripheral Blood in Myelodysplastic Syndromes”

October 28
Christina Sigurdson, D.V.M., Ph.D.
UC San Diego Pathology

November 4
Geoff Wahl, Ph.D.
The Salk Institute
“Exploring Links Between Development, Stem Cells, and Breast Cancer”

Wednesday, November 13
Hideyuki Okano, M.D. Ph.D.
Graduate School of Medicine, Keio University
"Neuroscience Using iPS Cell Technologies and Transgenic Non-human Primates"

November 18
Wendy Campana, Ph.D.
UC San Diego Anesthesiology
"Schwann Cell Signaling in Regeneration and Chronic Neuropathic Pain"

December 2
Lishan Su, Ph.D.
University of North Carolina School of Medicine
“Humanized Liver in Mice”

December 9
Robert Wechler-Reya, Ph.D.
Sanford Burnham Medical Research Institute, La Jolla
“Meddling with Medullobastoma: Manipulating Mice to Cure Brain Tumors”

December 16
Maurizio Zanetti, M.D.
UC San Diego Medicine
“Cancer, Stress, and Immunity: Facts and Hypotheses”

January 6
Razelle Kurzrock, M.D.
UC San Diego Moores Cancer Center
“Cancer Therapy in the OMICS Era”

January 13
Stephanie Cherqui, Ph.D.
UC San Diego – Department of Pediatrics
“Hematopoietic Stem Cell Gene Therapy for Cytinosis: A New Hope for a Multi-systemic Degenerative Disorder”

January 27
Ron Firestein, M.D., Ph.D.
“Mining the Colon Cancer Genome for New Therapeutic Targets”

February 3
Linda Ferrell, M.D.
UCSF – Department of Pathology
“Fatty Liver Disease: Liver Pathology Manifestations of the Obesity Epidemic”

February 10
Rafael Bejar, M.D., Ph.D.
UC San Diego Moores Cancer Center
“Novel Insights into the Molecular Genetics of Myelodysplastic Syndrome”

February 24
Christopher C. Glembotski, Ph.D.
San Diego State University
“Roles for the Unfolded Protein Response in the Heart”

March 3
Shane Meehan, M.D.
The University of Chicago
"Pathologic Origins of Pauci-immune Necrotizing and Crescentic Glomerulonephritis"

March 10
Catriona Jamieson, M.D., Ph.D.
UC San Diego – Moores Cancer Center
“Malignant Progenitor Reprogramming: Biologic and Therapeutic Implications”

March 17
Alissa Weaver, M.D., Ph.D.
Vanderbilt University Medical Center
“Control of Cancer Invasiveness by Endolysosomal Secretion”

March 24
Steven Finkbeiner, M.D., Ph.D.
UCSF - Glastone Institute of Neurological Disease
"Insights into Mechanisms of Neurodegenerative Disease from Longitudinal Single cell Analysis of Primary Neuron and Patient-derived Human iPSC Models"

March 31
Sarah Murray, Ph.D.
UC San Diego - Department of Pathology
"Clinical Genomics and Personalized Medicine"

April 7
Terry Gaasterland, Ph.D.
UC San Diego - Scripps Institute of Oceanography
"Interpreting Non-coding, Regulatory Variants Found in Exome Sequencing: A Study in Glaucoma"

April 14
Judith Varner, Ph.D.
UC San Diego - Moores Cancer Center
"Innate Immunity as a Driving Force in Cancer"

April 21
Marta Margeta, M.D., Ph.D.
UCSF - Department of Pathology
"A Crosstalk Between Synaptic and Antioxidant Signaling:The Role of Neuron-Glia Interactions"

April 28
No PRLS talk

April 29 - Special Lecture at 1:30 p.m.
Kevin Roth, M.D., Ph.D.
University of Alabama at Birmingham
"Autophagy Targeted Therapy for Malignant Glial Neoplasm"

April 30 - Special Lecture at noon
Gene Siegal, M.D., Ph.D.
University of Alabama at Birmingham
"Bone Neoplasia in the 21st Century - Using Fibrous Dysplasia as the Model for How Far We’ve Come"

May 5
Pascal Gagneux, Ph.D.
UC San Diego - Cellular and Molecular Medicine
"Sugar Coated Genomes - The Sprerm Sialome Provides Temporary Stealth for the Allogeneic Gamet"

May 12
Wing-Chung (John) Chan, M.D.
City of Hope Medical Center
"The Molecular Pathogenesis of T and NK Cell Lymphoma"

May 19
Elizabeth A. Winzeler, M.D.
UC San Diego - Division of Infectious Diseases
"Using Chemical Genetics and Genomics to Find the Next Generation Drugs for Malaria Eradication and Elimination"

June 2
Kelly Frazer, Ph.D.
UC San Diego – Department of Pediatrics, Institute for Genomic Medicine
“Genomic Architecture and Evolution of Chronic Lymphocytic Leukemia Defined by
Sequencing and Methylation Profiling”

June 9
Brett Lowenthal, M.D. – Resident, PGY-2 – UC San Diego Department of Pathology
“Discontinuous Unilateral Adenocarcinoma In Prostate Core Biopsies: A Diagnostic Challenge with Clinical Impact”
Petrus De Jong, M.D. – Postdoc, Eyal Raz Lab – UC San Diego Department of Medicine
“Regulation of Intestinal Tumorigenesis by Epithelial TRPV1 Signaling”

June 16
Uptal Das, Ph.D. – Project Scientist, Subhojit Roy Lab –UC San Diego Department of Neurosciences
"Neuronal Activity and APP/BACE Convergence: Molecular Events Underlying Amyloid Beta Generation"
Underlying Amyloid Beta Generation”
Ioannis Drygiannakis, Ph.D. – Postdoc, Peter Ernst Lab – UC San Diego Department of Pathology
“The Role of Adenosine in Regulating Lymphocyte Fate in Colitis”

June 23
Ken Fujimura, Ph.D. – Postdoc, Rich Klemke Lab – UC San Diego Department of Pathology
“A Hypusine-eIF5A-PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer”
Jay Desgrosellier, Ph.D. – Project Scientist, David Cheresh Lab – Moores UC San Diego Cancer Center
“An integrin αβ3-Src-Slug Pathway Drives Stemness in Development and Cancer”

June 30
Karra Muller, M.D., Ph.D. – Neuropathology Fellow – UC San Diego Department of Pathology
“VEGF Receptor and Cellular Senescence in Glioblastoma”
Huawei Wang, Ph.D. – Postdoc, Rich Klemke Lab – UC San Diego Department of Pathology
“PEAK1, a New Tyrosine Kinase Necessary for Angiogenesis”


September 10, 2012
Lawrence Goldstein, Ph.D.
Investigator, Howard Hughes Medical Institute; Distinguished Professor; Department of Cellular and
Molecular Medicine and Department of Neurosciences; Director, UC San Diego Stem Cell Program
UC San Diego School of Medicine
Probing Mechanisms of Neurodegenerative Disease with Human Pluripotent Stem cells

September 17, 2012
David Pride, M.D., Ph.D.
Assistant Professor of Pathology; Associate Director of Microbiology
UC San Diego School of Medicine
Effect of living environment on human viral ecology

Wednesday, September 19, 2012
noon to 1:00 p.m. in the Skaggs School of Pharmacy Building, Room 1186
David C. Williams Jr, MD, PhD
Assistant Professor, Department of Pathology
Virginia Commonwealth University
Targeted disruption of the NuRD chromatin remodeling complex: structure and dynamics of the MBD2
and MBD3 proteins

September 24, 2012
Hua Yu, Ph.D.
Professor, Cancer Immunotherapeutics & Tumor Immunology; Co-leader, Cancer Immunotherapeutics
Program, Comprehensive Cancer Center; Member, Cancer Immunotherapeutics Program,
Comprehensive Cancer Center
City of Hope
Role of STAT3 in transformed and non-transformed cells in tumors

Wednesday, September 26, 2012
noon to 1:00 p.m. in the Skaggs School of Pharmacy Building, Room 1186
Donna Hansel, M.D., Ph.D.
Associate Professor of Pathology and Laboratory Medicine Institute, Cleveland Clinic Lerner College of
Case Western Reserve University
Molecular Targets in Bladder Cancer

October 1, 2012
Cristian Achim, M.D., Ph.D.Associate Professor of Psychiatry and Pathology
UC San Diego School of Medicine
Markers of neurodegeneration in aging with HIV

October 8, 2012
Maike Sander, M.D.
Professor of Pediatrics and Cellular & Molecular Medicine
UC San Diego School of Medicine
Cell plasticity in the pancreas in development and disease

October 15, 2012
Rachel Schrier, Ph.D.
Associate Research Immunologist, Division of Infectious Disease, Department of Pathology
UC San Diego School of Medicine
Dendritic Cell Enhancement of T-Cell Responses/Contributions of CD8 T-Cells to Pathogenesis of HIV
associated Neurocognitive Disorder

October 22, 2012
Andrew Kummel, Ph.D.
Professor of Chemistry and Biochemistry; Director of UCSD Nano Medicine Lab
UC San Diego School of Medicine
Nanoparticles and Imaging Algorithms for Intra-Operative Tumor Localization & Automated Margin

October 29, 2012
Sujan Shersta, Ph.D.
Associate Professor, Division of Vaccine Discovery
La Jolla Institute for Allergy & Immunology
Protective versus Pathogenic Effects of Dengue Vaccination

November 5, 2012
Jacek Skowronski, PhD
Professor, Department of Molecular Biology and Microbiology
Case Western Reserve University
Inhibition of HIV infection by SAMHD1

November 19, 2012
Nunzio Bottini, M.D., Ph.D.
Associate Professor, Cellular Biology
La Jolla Institute for Allergy & Immunology
PPTPN22 & Autoimmunity; from old Concepts to New Perspectives

November 26, 2012
No lecture

December 3, 2012
Jonathan Lin, M.D., Ph.D.
Assistant Professor of Pathology
UC San Diego School of Medicine
Title TBA
December 10, 2012
John Lowe, M.D.
Senior Director of Pathology
Title TBA

January 7, 2013
R. Michael Roberts, Ph.D.
Curators’ Professor of Animal Science, Biochemistry, & Veterinary Pathobiology
University of Missouri
Unidirectional Conversion of Human ESC & iPSC to Trophoblast & its Sub-lineages

January 14, 2013
Alysson Muotri, Ph.D.
Assistant Professor, Department of Pediatrics and Cellular & Molecular Medicine
UC San Diego
Title TBA

January 28, 2013
Mana Parast, M.D., Ph.D.
Assistant Professor, Department of Pathology
UC San Diego
Title TBA

February 4, 2013
Albert La Spada, M.D., Ph.D.
Professor of Pediatrics, Cellular & Molecular Medicine and Neurosciences
Vice Chair & Division Head of Genetics, Department of Pediatrics & Rady Children’s Hospital – San Diego
Associate Director, Institute for Genomic Medicine, UC San Diego
Neurodegenerative Disease Pathogenesis Links Metabolic Control Pathways with Proteostasis Regulation

February 11, 2013
Michael Busch, M.D., Ph.D.
Director, Blood Systems Research Institute
Senior Vice President, Research and Scientific Affairs, Blood Systems Inc., Scottsdale, Arizona
Professor of Laboratory Medicine, UC San Francisco
Emerging Viral Infections & Blood Safety

February 18, 2013
President's Day Holiday - no lecture

February 25, 2013
Kumar Sharma, M.D., F.A.H.A.
Professor of Medicine, Division of Nephrology-Hypertension
Director, Translational Research in Kidney Disease, UC San Diego
Mitochondria, Metabolomics, and Diabetic Complications

March 4, 2013
Yang Xu, Ph.D.
Professor, Division of Biological Sciences
UC San Diego
Challenges in the Clinical Application of Human Embryonic Stem Cells

March 11, 2013
Steven F. Dowdy, Ph.D.
Professor, Department of Cellular & Molecular Medicine
UC San Diego
RNAi Therapeutics: The Ultimate Drug or Just an 800 Pound Gorilla?

March 18, 2013
Kumar Sharma, M.D., F.A.H.A.
Professor, Department of Reproductive Medicine
UC San Diego
An X-Linked Gene Cluster in Search of a Purpose

March 25, 2013
No lecture

April 1, 2013
Anthony A. Horner, M.D.
Associate Professor of Medicine
Department of Rheumatology, Allergy, & Immunology
UC San Diego
Studying House Dust Bioactivities to Understand Allergic Risk

April 8, 2013
Robert Fitzgerald, M.D.
Professor, Department of Pathology
Director of Toxicology & Associate Director of Clinical Chemistry
UC San Diego
Clinical Applications of Mass Spectrometry

April 15, 2013
Michael J. Soares, Ph.D.
Distinguished Professor
Institute for Reproductive Health and Regenerative Medicine
University of Kansas Medical Center
Adaptations at the Maternal-Fetal Interface

April 22, 2013
Brian Eliceiri, Ph.D.
Associate Professor, Department of Surgery
UC San Diego
Microglia Activation in the Brain: A Balance with the Brain Barrier?

April 29, 2013
Jean Y. J. Wang, Ph.D.
Distinguished Professor of Medicine
Associate Director of Basic Research
UC San Diego Moores Cancer Center
EnABLing Apoptotic Response in Cancer Therapies

May 6, 2013
Jean Y. J. Wang, Ph.D.
Distinguished Professor of Medicine
Associate Director of Basic Research
UC San Diego Moores Cancer Center
EnABLing Apoptotic Response in Cancer Therapies

May 13, 2013
Karen L. Christman, Ph.D.
Assistant Professor, Department of Bioengineering
Sanford Consortium for Regenerative Medicine
UC San Diego
Injectable Biomaterials for Treating Cardiovascular Disease

May 20, 2013
No lecture

May 27, 2013
Memorial Day Holiday - no lecture

June 3, 2013
Adam Bagg, M.D.
Professor of Pathology and Laboratory Medicine
Director, Hematology
Medical Director, Clinical Cancer Cytogenetics
University of Pennsylvania
Contemporary Use of Genetic Testing in B-Cell Lymphomas


September 12, 2011
Peter Ernst, D.V.M., Ph.D.
Professor of Pathology, UCSD
“The varying roles for purine metabolism on immune regulation in the gastrointestinal tract”

September 19, 2011
Robert Farese, M.D.
Professor of Medicine, Biochemistry and Biophysics, UCSF
"How cells fatten up: Mechanisms of fat synthesis and storage"

September 26, 2011
Gen-Sheng Feng, Ph.D.
Professor of Pathology, UCSD
"Oncogene and Tumor Suppressor Gene: from "Definitive" to "Paradoxical" "

October 3, 2011
Richard Schwab, M.D.
Assistant Clinical Professor of Medicine; Director, Moores UCSD Cancer Center Biorepository
"A Medical Oncology Perspective on Cancer Biomarkers"

October 10, 2011
Michael Kalichman
Professor of Pathology; Director, UCSD Research Ethics Program
"Authorship: Are there any standards?"

October 17, 2011
Jing Yang, Ph.D.
Assistant Professor of Pharmacology and Pediatrics, UCSD
"A New Twist on Tumor Metastasis"

October 24, 2011
David Rimm, M.D., Ph.D.
Professor of Pathology; Director, Medical Studies, Yale University School of Medicine
"Companion Diagnostics: The Pathologist as the Prescribing Physician"

October 31, 2011
Subhojit Roy, Ph.D.
Assistant Professor of Neurosciences
"Alpha synuclein at the synapse: the Good, the Bad and the Ugly"

November 7, 2011
Robert Petras, M.D., FCAP, FACG
National Director of Gastrointestinal Pathology Services, AmeriPath
"Inflammatory Bowel Disease: Greatest Hits"

November 14, 2011Lesley Ellies, Ph.D.
Associate Professor of Pathology, UCSD
"Luminal and basal-EMT mammary tumors arise from a single multipotent cancer stem cell"

November 21, 2011
Jennifer Isaacs, Ph.D.
Assistant Professor of Cell and Molecular Pharmacology, Medical University of South Carolina
"New tricks for an ancient protein: Extracellular Hsp90 (eHsp90) as a central regulator of cancer

November 28, 2011
Cheryl Rock, Ph.D., R.D.
Professor of Family and Preventative Medicine, UCSD
"Weight, Overweight & Obesity for Breast Cancer Survivors"

December 5, 2011
Robert Newbury, M.D.
Professor of Pathology, UCSD
"Eosinophilic Esophagitis: An update"

December 12, 2011
Stuart Lipton, M.D.
Professor and Scientific Director, Sanford-Burnham Medical Research Institute
"Redox Stress and NMDA Receptors in Alzheimer’s and Parkinson’s Diseases: Mechanisms and
Therapeutic Implications"

January 9, 2012
Joseph L. Witztum, M.D.
Professor of Medicine, UCSD
"Oxidation-Specific Epitopes are Targets of Innate Immunity: Implications for Health and Disease"

January 23, 2012
John H. Sinard, M.D., Ph.D.
Professor of Pathology and of Ophthalmology and Visual Science; Director, Pathology Informatics; Director, Pathology Residency Program; Director, Pathology Autopsy Program, Yale School of Medicine
"Better pathology through Informatics: Tools to improve clinical workflow"

January 30, 2012
Lee Grimes, Ph.D.
Director, Cancer Pathology Program of the Division of Experimental Hematology and the Division of Pathology
Associate Professor, Department of Pediatrics, University of Cincinnati
"An ancient antagonism underlies Hox based oncogenesis; curing AML with RNA therapeutics"

February 6, 2012
Lawrence Weiss, M.D.
Senior Consulting Pathologists, Clarient, Inc. and Chairman Emeritus, City of Hope
"Association of Epstein-Barr Virus with Malignant Lymphoma"

February 13, 2012
Klaus Ley, M.D.
Professor and Head, Division of Autoimmune Research, La Jolla Institute for Allergy & Immunology
"Multiphoton live cell microscopy of atherosclerosis"

February 27, 2012
Michael Croft, Ph.D.
Professor and Head, Division of Immune Regulation, La Jolla Institute for Allergy & Immunology
"Control of Asthma and Airway Inflammation by Molecules in the TNF Family"

March 5, 2012
Michael Peterson, M.D., Ph.D.
Associate Professor of Pathology, UCSD
"Pathologic Evaluation of Hepatocellular Carcinoma and Other Nodular Liver Lesions"

March 12, 2012
Grace Lin, M.D., Ph.D.
Assistant Professor of Pathology, UCSD
"Napsin A: Utility in Identifying Primary Mucinous Lung Adenocarcinomas Versus Mucinous Metastasis"

April 2, 2012
H. Elizabeth Broome, M.D.
Professor of Pathology; Director of the Clinical Hematology Laboratory; Associate Director of the Immunogenetics and Transplantation Laboratory; UCSD
"Usefulness of Chronic Lymphocytic Leukemia (CLL) Immunophenotype for Differential Diagnosis and Minimal Residual Disease Testing"

April 9, 2012
Hilde Cheroutre, Ph.D.
Division Head and Professor, Autoimmune Research; Developmental Immunology; La Jolla Institute for Allergy & Immunology
"Mucosal T Cells March to the Beat of a Different Drummer"

April 16, 2012
Lars Eckmann, M.D.
Associate Professor of Medicine, UCSD
"Defending the intestinal lumen against the off-shore pathogen Giardia"

April 23, 2012
Mel B. Feany, M.D., Ph.D.
Associate Professor, Department of Pathology, Harvard Medical School
Associate Pathologist and Neuropathologist, Pathology, Brigham And Women's Hospital
"Genetic Analysis of Neurodegeneration"

April 30, 2012
Judith Coppinger, M.D.
Assistant Professor of Pathology, UCSD
"Using Mass Spectrometry Based Proteomics to Drive Biological Discovery"

May 7, 2012
John Goldblum, M.D.
Chair, Department of Anatomic Pathology, Cleveland Clinic
"Controversies in the Diagnosis of Barrett's Esophagus and BE-related Dysplasia".

May 14, 2012
Joseph Madri, M.D., Ph.D.
Professor of Pathology, Yale School of Medicine
"Endothelial Cell-Neural Stem Cell Signaling Nodes in the Neurovascular Niche"

May 21, 2012
Louise Laurent, M.D., Ph.D.
Assistant Professor of Reproductive Medicine, UCSD
"Epigenetic and Transcriptional Variability in Human Pluripotent Stem Cells and their Derivatives"


Click here to view the current Pathology Conference schedule.

For more information, please contact Tyler Badilla at 858-534-4323 or