CHARM ⬌ GRTC Collaborations
The surface of all bacteria and human cells are heavily decorated with carbohydrate structures, and therefore all host-pathogen interactions are influenced in important ways by glycan and glycan receptor interactions. CHARM and GRTC faculty are deciphering these molecular events to identify new targets to interrupt bacterial virulence, boost host innate and adaptive immunity, provide new biomarkers of infection, develop bacterial carbohydrate vaccines, improve antibiotic drug delivery, and mitigate the host inflammatory damage during invasive infection and sepsis.