CHARM ⬌ CMBB Collaborations
CHARM and CMBB faculty conduct many studies evaluating the antibiotic and immune boosting potential of novel chemicals isolated from marine actinomycetes, cyanobacteria and sponges, with a focus on MRSA and MDR Gram-negative pathogens, including treatment studies in animal models of infection. Sophisticated approaches including genome mining, heterologous biosynthesis, and chemoenzymatic total synthesis are brought to bear on this work.