Research

Seema S. Aceves, MD, PhD

NIH funded study (R01) on the mechanisms of tissue remodeling in eosinophilic esophagitis (EoE) (the role of pro-inflammatory and pro-fibrotic molecules), diagnosis (biomarker discovery), and treatment options and their effects on disease complications such as esophageal remodeling
DOD funded study of the genetics of food allergic EoE
Executive Council member, The International Gastrointestinal Eosinophil Research Network
Editorial Board of Journal of Allergy and Clinical Immunology
New Grant: AAAAI/APFED HOPE Pilot Project in Eosinophilic Diseases

John F. Bastian, MD

Jane C. Burns, MD

The pathophysiology, immunology, diagnosis, etiology, treatment, genetics, epidemiology and history of Kawasaki disease
A multicenter, randomized placebo-controlled clinical trial of infliximab plus IVIG for primary treatment of Kawasaki disease
Call-back study of adolescents and young adults with a history of Kawasaki disease in childhood

Johanna Chang, MD

Alessandra M. Franco, MD, PhD

T-cell repertoire in Kawasaki disease
Biological function of IVIG therapy
Immune-regulation in infants and young children
Cytotoxic T cell biology
Carbohydrate T cell recognition
Designer glycopeptides containing tumor-associated carbohydrate antigens as vaccines for prevention/treatment of epithelial cancer

Hal M. Hoffman, MD

Role of innate immunity and IL-1 therapy in autoinflammatory disorders
Characterization of cryopyrin inflammasome function using a number of experimental models, including in vitro cell lines, ex vivo monocytes and genetically modified mice
Genetic basis of rare inherited disorders including congenital diarrheas, rare urticarial, and immunodeficiency, and autoinflammatory disorders
Inflammatory mechanisms involved in periodic fever disorders of childhood

Anthony A. Horner, MD

Characterization of the molecular content and immunological activities of sterile house dust extracts to better define the immunomodulatory role living environments have on the genesis of allergic diseases
Translational studies to determine if house dust extract bioactivities are predictive of the intrinsic allergic risk associated with being raised in their homes of origin
Treatment of allergic diseases with toll-like receptor ligands and other immune-modulatory molecules
Development of a new generation multiplex assay to detect IgE to peanut allergens and to measure their binding affinities (Collaboration with Genalyte)

Stephanie Leonard, MD

Principle Investigator of Clinical trial at RCHSD site, for novel treatments of peanut allergy

Karin Peterson, MD, PhD

Robert M. Sheets, MD

Clinical trials of new treatments for pediatric rheumatologic diseases including the TREAT study

Chisato Shimizu, MD

Ilona S. Szer, MD

Conducts several clinical trials of new treatments for juvenile arthritis and pediatric rheumatologic diseases
As member of CARRA, Dr. Szer participates in the evaluation and implementation of multicenter studies in Pediatric Rheumatology
Chair of DSMB for two current trials