Dr. Mana Parast's PubMed Articles

Representative Publications (Basic Research)


  1. Farah O, Nguyen C, Tekkatte C, Parast MM.  Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction.  Trophoblast Research 2020; in press.
  2. Horii M, Bui T, Touma O, Cho HY, Parast MM.  An improved two-step protocol for trophoblast differentiation of human pluripotent stem cells.  Curr Protoc Stem Cell Biol. 2019; 50(1):e96. PMID: 31479595
  3. Pham J, Arul Nambi Rajan K, Li P, Parast MM.  The role of Sirtuin1-PPARg axis in placental development and function. J Mol Endocrinol 2018; 60(4):R212. PMID: 29467141
  4. Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, Arul-Nambi-Rajan K, Nelson KK, Chang CW, Moretto-Zita M, Natale DR, Laurent LC, Parast MM. Comparative analysis of mouse and human placentas across gestation reveals species-specific regulators of placental development.  Development 2018; 145(2). Pii: dev156273. PMCID: PMC5825847
  5. Arul-Nambi-Rajan K, Khater M, Soncin F, Pizzo D, Moretto-Zita M, Pham J, Stus O, Iyer P, Tache V, Laurent LC, Parast MM.  Sirtuin1 is required for proper trophoblast differentiation and placental development in mice.  Placenta 2018; 62:1-8. PMCID: PMC5805473
  6. Chang CW, Wakeland AK, Parast MM. Trophoblast lineage specification, differentiation and their regulation by oxygen tension. J Endocrinol 2018; 236(1):R43-R56. PMCID: PMC5741095
  7. Wakeland AK, Soncin F, Moretto-Zita M, Chang CW, Horii M, Pizzo D, Nelson KK, Laurent LC, Parast MM. Hypoxia directs human extravillous trophoblast differentiation in a HIF-dependent manner. Am J Pathol 2017; 187(4):767-780. PMCID: PMC5397702
  8. Horii M, Li Y, Wakeland AK, Pizzo DP, Nelson KK, Sabatini K, Laurent LC, Liu Y, Parast MM. Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A. 2016; 113(27):E3882-91. PMCID: PMC4941448
  9. Moretto Zita M, Soncin F, Natale D, Pizzo D, Parast M. Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation. J Biol Chem 2015; 290(50):30152-62. PMCID: PMC4705987
  10. Horii M, Moretto-Zita M, Nelson KK, Li Y, Parast MM. MTA3 regulates differentiation of human cytotrophoblast stem cells. Placenta 2015, 36(9):974-80. PMCID: PMC4554833
  11. Soncin F, Natale D, Parast MM. Signaling pathways in mouse and human trophoblast differentiation: a comparative review. Cell Mol Life Sci. 2015; 72(7):1291-302. PMCID: PMC4366325
  12. Li Y, Moretto-Zita M, Leon-Garcia S, Parast MM. p63 Inhibits Extravillous Trophoblast Migration and Maintains Cells in a Cytotrophoblast Stem Cell-Like State. Am J Pathol. 2014; 184(12):3332-43. PMCID: PMC4258507
  13. Li Y, Parast MM. BMP4 regulation of human trophoblast development. Int J Dev Biol 2014; 58(2-4):239-46. PMID: 25023690
  14. Li Y, Moretto-Zita M, Soncin F, Wakeland A, Wolfe L, Leon-Garcia S, Pandian R, Pizzo D, Cui L, Nazor K, Loring JF, Crum CP, Laurent LC, Parast MM. BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state. Development 2013; 140(19):3965-76. PMCID: PMC3775414
  15. Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM. Hypoxia and Trophoblast Differentiation: A Key Role for PPARγ. Stem Cells Dev 2013; 22(21):2815-24. PMCID: PMC3804243
  16. Quinn KH, Parast MM. Decidual regulatory T cells in placental pathology and pregnancy complications. Am J Reprod Immunol 2013; 69(6):533-8. PMID: 23384284
  17. Quinn KH, LaCoursiere DY, Cui L, Bui J, Parast MM. The Unique Pathophysiology of Early-Onset Severe Preeclampsia: Role of Decidual T Regulatory Cells. J Reprod Immunol 2011; 91(1-2):76-82. PMID: 21782252
  18. Parast MM, Yu H, Ciric A, Salata MW, Davis V, Milstone DS. PPARg regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation.  PLoS One 2009; 4(11):e8055. PMCID: PMC2778869
  19. Lee Y, Kim K-R, McKeon F, Yang A, Boyd TK, Crum CP, Parast MM.  A Unifying Concept of Trophoblastic Differentiation and Malignancy Defined by Biomarker Expression.  Hum Pathol 2007; 38(7):1003-1013. PMID: 17397906


    Representative Publications (Clinical/Translational Research)

  1. O'Brien LM, Warland J, Stacey T, Heazell AEP, Mitchell EA; STARS Consortium (including Parast M). Maternal sleep practices and stillbirth: Findings from an international case-control study. Birth. 2019; Epub. PMID: 30656734
  2. Palmsten K, Nelson KK, Laurent LC, Park S, Chambers CD, Parast MM. Subclinical and clinical chorioamnionitis, fetal vasculitis, and risk for preterm birth: A cohort study. Placenta. 2018; 67:54-60. PMID: 29941174
  3. Leon-Garcia SM, Roeder HA, Nelson KK, Liao X, Pizzo DP, Laurent LC, Parast MM, LaCoursiere DY. Maternal obesity and sex-specific differences in placental pathology. Placenta 2016; 38:33-40. PMID: 26907380
  4. Warland J, O'Brien LM, Heazell AEP, Mitchell EA, and the STARS Consortium (including Parast M). An international internet survey of the experiences of 1,714 mothers with a late stillbirth:  the STARS cohort study. BMC Pregnancy Childbirth 2015, 15:172
  5. Roeder HA, Dejbakhsh SZ, Parast MM, Laurent LC, Woelkers DA. Abnormal uterine artery Doppler velocimetry predicts adverse outcomes in patients with abnormal analytes. Pregn Hypertension. 2014; 4:296-301. PMID: 26104819
  6. Wolfe LM, Thiagarajan RD, Boscolo F, Taché V, Coleman RL, Kim J, Kwan WK, Loring JF, Parast M, Laurent LC. Banking placental tissue: an optimized collection procedure for genome-wide analysis of nucleic acids. Placenta 2014; 35(8):645-54. PMID: 24951174
  7. Ryan WD, Trivedi NA, Benirschke K, LaCoursiere DY, Parast M. Placental histologic criteria for diagnosis of cord accident:  sensitivity and specificity.  Pediatr Dev Pathol 2012; 15(4):275-80. PMID: 22400796
  8. Tache V, LaCoursiere DY, Saleemuddin A, Parast MM.  Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical preeclampsia and villous hypermaturity.  Hum Pathol 2011; 42(9):1283-8. PMID: 21334711
  9. Saleemuddin A, Tantbirojn P, Sirois K, Crum CP, Boyd TK, Tworoger S, Parast MM.  Obstetric and perinatal complications in placentas with fetal thrombotic vasculopathy.  Pediatr Dev Pathol 2010; 13(6):459-64. PMID: 20438299
  10. Tantbirojn P, Saleemuddin A, Sirois K, Crum CP, Boyd TK, Tworoger S, Parast MM.  Gross abnormalities of the umbilical cord: related placental histology and clinical significance. Placenta 2009; 30(12):1083-88. PMID: 19853300
  11. Tantbirojn P, Crum CP, Parast MM.  Pathophysiology Of Placenta Creta:  A Histologic Assessment of Interstitial and Endovascular Extravillous Trophoblast.  Placenta 2008; 29(7):639-45. PMID: 18514815
  12. Parast MM, Crum CP, Boyd TK. Placental Histologic Criteria for Umbilical Blood Flow Restriction in Unexplained Stillbirth. Hum Pathol 2008; 39(6):948-53. PMID: 18430456.