Recent Publications:

1.Neuroinflammation plays a critical role in cerebral cavernous malformation disease. Catherine Chinhchu Lai*, Bliss Nelsen*, Eduardo Frias-Anaya*, Helios Gallegos-Gutierrez*, Marco Orecchioni, Hao Sun,  Klaus Ley, Brendan Gongol, Miguel A. Lopez-Ramirez. *contributed equally. BioRxiv, 2022.2005.2009.491214 (2022).

2.Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4 + T Cells. Frederic Lagarrigue, Boyang Tan, Qinyi Du,†Zhichao Fan, Miguel A. Lopez-Ramirez, Alexandre R. Gingras, Hsin Wang,  Weiwei Qi, and Hao Sun. The Journal of Immunology, 2022

3.Snellings A.D, Hong C.C. Ren A.A. Lopez-Ramirez M.A. Girard R. Srinath A. Marchuk D.A. Ginsberg M.H. Awad I.A. Kahn M.L. Circulation Research, 2021. 

4.Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. M. A. Lopez-Ramirez, S. I. Soliman, P. Hale, C. C. Lai, A. Pham, E. Estrada, S. McCurdy, R. Girard, R. Verma, T. Moore, R. Lightle, N. Hobson, R. Shenkar, O. Poulsen, G. G. Haddad, R. Daneman, B. Gongol, H. Sun, F. Lagarrigue, I.A. Awad, M. H. Ginsberg. Journal of Clinical Investigation, 2021.

5. Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. M.A. Lopez-Ramirez, Mark K. Haynes, Preston Hale, Killian Oukoloff, Matthew Bautista, Brendan Gongol, John Y. Shyy, Carlo Ballatore, Larry A. Sklar, Alexandre R. Gingras. FASEB BioAdvances, 2021.

6. Distinct integrin activation pathway for effector and regulatory T cell trafficking and function. Sun H., Lagarrigue F, Wang H, Fan Z., Lopez-Ramirez MA, Chang JT, Ginsberg M.H. Journal of Experimental Medicine. 2021.

7. Generation of in vitro models of Cerebral Cavernous Malformations disease. Hale P., Soliman S.I., Lopez-Ramirez MA. Springer Nature. Methods Mol Biol. 2020.

8. A Flexible Kink in the Transmembrane Domain impairs B2 Integrin Extension and Cell Arrest from Rolling.Sun H., Fan Z., Gingras A.R., Lopez-Ramirez MA, Ginsberg M.H., Ley K. Journal of Leukocyte Biology. 2020.

9. Talin-1 is the principal platelet Rap1 effector of integrin activation. Lagarrigue F, Paul DS, Gingras AR, Valadez AJ, Sun H, Lin J, Cuevas MN, Ablack JN, Lopez-Ramirez MA, Bergmeier W, Ginsberg MH. Blood. 2020.

10. b7 integrin inhibition can increase intestinal inflammation by impairing homing of CD25 HI-floxP3+ regulatory T cells. Sun H., Kuk w, Rivera-Nieves J, Lopez-Ramirez MA, Eckmann L, Ginsberg M.H. Cellular and Mol Gast and Hepatology. 2020.

11. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformation. Koskimaki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrion-Penagos J, Lyne S, Zeineddine HA, Shi C, Shenkar R, Romanos D, Avner K, Srinath A, Shen L, Detter MS, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrede J, Ginsberg M, Kahn ML, Markchuk DA, Girard R, Awad IA. Acta Neuropath commun. 2019.

12. Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH. J Cell Biol. 2019.

13. Biomarkers of cavernous angioma with symptomatic hemorrhage. Lyne S.B., Girard R, Koskimaki J, Zeineddine HA, Li Y, Stadnik A, Moore T, Lightle R, Cao Y, Shi C, Avner K, Shenkar R, Carrion-Penagos J, Polster SP, Romanos D, Akers A, Lopez-Ramirez MA, Whitehead KJ, Kahn ML, Ginsberg M, Markchuk DA, Awad IA. JCI insight, 2019.

14. Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. Koskimäki J, Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Lyne S, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Carrión-Penagos J, Romanos S, Fonseca G, Lopez-Ramirez MA, Chapman EM, Popiel E, Tang AT, Akers A, Faber P, Andrade J, Ginsberg M, Derry WB, Kahn ML, Marchuk DA, Awad IA. JCI Insight. 2019

15. Cerebral cavernous malformations form an anticoagulant vascular domain. Lopez-Ramirez MA., Pham A, Girard R, Yamashita A, Hale P, Romero I.A, Lagarrigue F, Awad I.A, Mosnier L, Ginsberg M.H. Blood. 2019.

16. Phenotypic Characterization of Murine Models of Cerebral Cavernous Malformations. Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA. Lab Investigation. 2019.