Publications from the Hoffman Lab
A list of selected recent publications is below. See full list of publications from PubMed

Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman, HM. Divergence of IL-1, IL-18 and cell death in NLRP3 inflammasomopathies. J Clin Invest. Oct 1 2013; doi:10.1172/JCI71543. PMID:24084736

McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD, (2012) Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models. J Immunol 189(6):2707-11. PMCID: PMC3495128

Ombrello MJ, Remmers EF, Sun G, Freeman AF, Datta S, Torabi-Parizi P, Subramanian N, Bunney TD, Baxendale RW, Martins MS, Romberg N, Komarow H, Aksentijevich I, Kim HS, Ho J, Cruse G, Jung MY, Gilfillan AM, Metcalfe DD, Nelson C, O'Brien M, Wisch L, Stone K, Douek DC, Gandhi C, Wanderer AA, Lee H, Nelson SF, Shianna KV, Cirulli ET, Goldstein DB, Long EO, Moir S, Meffre E, Holland SM, Kastner DL, Katan M, Hoffman HM, Milner JD. (2012) Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions N Engl J Med. 366:4:330-8. PMCID: PMC3298368.

Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 482:7384:179-85. PMCID: PMC3276682

Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM (2009). Animal Models of Inflammasomopathies Reveal Roles for Innate but not Adaptive Immunity. Immunity, 30: 6: 875-87. PMCID: PMC2759865

Rosengren S, Mueller JL, Anderson JP, Niehaus BL, Misaghi A, Anderson S, Boyle DL, Hoffman HM. (2007). Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia. J Allergy Clin Immunol, 119: 9: 991-6. PMID: 17320940

Stack J, Beaumont K, Larsen P, Straley K, Henkel G, Randle J, Hoffman HM (2005) IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol, 175:4: 2630-2634. PMID: 16081838