Publications from the Ginsberg Lab

A list of selected recent publications is below. See full list of publications from PubMed

Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor SS, Ginsberg MH. Alpha-4 integrins are type l cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol, 2007;4:415-421.

Petrich BG, Fogelstrand P, Partridge AW, Yousefi N., Ablooglu AJ, Shattil SJ, Ginsberg MH. The antithrombotic potential of selective blockade of talin-dependent integrin {alpha}llb{beta}3 (platelet GPllb-llla) activation. J Clin Invest, 2007;117:2250-2259.

Prager GW, Feral CC, Kim C, Han J, Ginsberg MH. CD98hc (SLC3a2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. J Biol Chem, 2007;282:24472.
Rose DM, Alon R, Ginsberg MH. Integrin modulation and signaling in leukocyte adhesion and migration. Immunol Rev, 2007;218:126-134.

Wegener KL, Partridge A, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID. Structural basis of integrin activation by talin. Cell, 2007;128:171-182.

Feral CC, Rose DM, Han J, Fox N, Silverman GJ, Kaushansky K, Ginsberg MH. Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest, 2006;116:715-723.

Goldfinger LE, Ptak C, Jeffrey ED, Shabanowitz J, Hunt DF, Ginsberg MH. RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J. Cell Biol, 2006;174:877-888.

Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. Reconstructing and deconstructing agonist-induced activation of integrin alphallbeta3. Curr Biol, 2006;16:1796-1806.

Kummer C, Ginsberg MH. New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation. Biochem Pharmacol, 2006;72:1460-1468.

Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Ginsberg MH. {alpha}4{beta} 1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the {alpha}4-cytoplasmic domain. J Cell Biol, 2005;171:1073-1084.